Aging and hemispheric cerebral lateralization
Centre Mémoire Ressource Recherche (CMRR) de la Région Centre et Médecine Interne Gériatrique, Hôpital Bretonneau et Université Rabelais, Tours, France. Psychologie & neuropsychiatrie du vieillissement
(Impact Factor: 0.89).
04/2008; 6(1):49-56. DOI: 10.1684/pnv.2008.0114
Cerebral hemispheric lateralization is an old concept, particularly concerning language. In children, numerous arguments favour a left hemispheric predisposition for language, but do not exclude its strengthening during childhood. In the elderly, changes in the lateralization have been described. Two models were proposed to explain these changes. The right hemi-aging model is supported by behavioral studies and the age-related asymmetry reduction model is documented by brain imaging studies. We review the data supporting the two models. The significance of this age-related asymmetry reduction is questionable. The dedifferentiation view suggests that bilateral activation in older adults reflects difficulty in recruiting specialized neural mechanisms. Age-related asymmetry reduction may also be evidence of compensatory mechanisms and plasticity of the aging brain. It is useful for understanding physiopathology of cognitive decline and rehabilitation potential of the aging brain.
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.