Article

Cutaneous head and neck melanoma: the old and the new.

Roswell Park Cancer Institute, Department of Head & Neck Surgery & Plastic Surgery, Buffalo, NY-14263, USA.
Expert Review of Anti-infective Therapy (impact factor: 2.65). 04/2008; 8(3):403-12. DOI:10.1586/14737140.8.3.403 pp.403-12
Source: PubMed

ABSTRACT The incidence rate of malignant melanoma has shown a rapid worldwide rise in recent years. The staging and management of head and neck melanoma presents some unique challenges. Surgery remains the cornerstone of treatment, while sentinel node biopsy is the most accurate staging modality for regional disease. The complex regional anatomy and lymphovascular drainage of this region may account for the increased biologic aggressiveness and treatment challenges of this disease. Improved understanding of the radiobiology of melanoma has resulted in new adjuvant radiotherapy approaches, yielding improved control rates. The treatment outcomes of metastatic head and neck melanoma remain disappointing but important progress has been made in the understanding of melanoma biology.

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Keywords

complex regional anatomy
 
control rates
 
cornerstone
 
Improved understanding
 
incidence rate
 
increased biologic aggressiveness
 
lymphovascular drainage
 
malignant melanoma
 
melanoma
 
melanoma biology
 
metastatic head
 
neck melanoma
 
neck melanoma presents
 
new adjuvant radiotherapy approaches
 
sentinel node biopsy
 
treatment challenges
 
treatment outcomes
 
unique challenges