Treatment of chronically depressed patients: A multisite randomized controlled trial testing the effectiveness of 'Cognitive Behavioral Analysis System of Psychotherapy' (CBASP) for chronic depressions versus usual secondary care

Department of Psychiatry and Institute for Research in Extramural Medicine, VU University Medical Center and Academic Outpatient Clinic for Affective Disorders, Stichting GGZBuitenamstel-de Geestgronden, The Netherlands.
BMC Psychiatry (Impact Factor: 2.24). 02/2008; 8:18. DOI: 10.1186/1471-244X-8-18
Source: PubMed

ABSTRACT 'Cognitive Behavioral Analysis System of Psychotherapy' (CBASP) is a form of psychotherapy specifically developed for patients with chronic depression. In a study in the U.S., remarkable favorable effects of CBASP have been demonstrated. However, no other studies have as yet replicated these findings and CBASP has not been tested outside the United States. This protocol describes a randomized controlled trial on the effectiveness of CBASP in the Netherlands.
The purpose of the present paper is to report the study protocol of a multisite randomized controlled trial testing the effectiveness of 'Cognitive Behavioral Analysis System of Psychotherapy' (CBASP) for chronic depression in the Netherlands. In this study, CBASP in combination with medication, will be tested versus usual secondary care in combination with medication. The aim is to recruit 160 patients from three mental health care organizations. Depressive symptoms will be assessed at baseline, after 8 weeks, 16 weeks, 32 weeks and 52 weeks, using the 28-item Inventory for Depressive Symptomatology (IDS). Effect modification by co morbid anxiety, alcohol consumption, general and social functioning and working alliance will be tested. GEE analyses of covariance, controlling for baseline value and center will be used to estimate the overall treatment effectiveness (difference in IDS score) at post-treatment and follow up. The primary analysis will be by 'intention to treat' using double sided tests. An economic analysis will compare the two groups in terms of mean costs and cost-effectiveness from a societal perspective.
The study will provide an answer to the question whether the favorable effects of CBASP can be replicated outside the US.
The Dutch Cochrane Center, NTR1090.

  • [Show abstract] [Hide abstract]
    ABSTRACT: Chronische depressies hebben de afgelopen jaren steeds meer aandacht gekregen als specifieke categorie binnen de heterogene groep van depressieve stoornissen. Niet alleen vanuit epidemiologisch, maar ook vanuit behandelperspectief. Er zijn aanwijzingen dat Cognitive Behavioral Analysis System of Psychotherapy (CBASP) voor patiënten met een chronisch verlopende depressie meerwaarde heeft boven de gangbare psychotherapieën1.
    04/2013; 5(2). DOI:10.1007/s13170-013-0021-z
  • [Show abstract] [Hide abstract]
    ABSTRACT: A simple and effective route for the direct synthesis of Mo2C coatings on graphite matrix is introduced for the joining of copper alloy heat sinks to graphite materials in Tokamak devices. The composition and microstructure of the Mo2C coatings on graphite, and the wetting behaviors of molten copper on coated and uncoated graphite were investigated. Results indicated that the Mo2C coatings were of several tens of micrometers depth in the graphite matrix. The coatings greatly improved the wettability of graphite by copper, and copper could be infiltrated into Mo2C-coated graphite matrix without external pressure. The strong interfacial bonding between copper and the graphite matrix was obtained by utilizing the mechanical interlocking within the space limitations of the graphite network. The Mo2C-modified graphite–copper samples resulted to have the average shear strength of 17±4MPa.
    Fusion Engineering and Design 12/2011; 86(12). DOI:10.1016/j.fusengdes.2011.07.007 · 1.15 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Background: It is widely agreed that chronic depression is difficult to treat, knowledge about optimal treatment approaches is emerging. Method: A multisite randomized controlled trial was conducted comparing the cognitive behavioral analysis system of psychotherapy (CBASP), a psychotherapy model developed specifically to treat chronic depression (n = 67) with care as usual (CAU; evidence-based treatments, n = 72) over a period of 52 weeks, with 23 sessions on average, in 3 outpatient clinics in the Netherlands. In both arms algorithm-based pharmacotherapy was provided. Patients (aged 18-65) met criteria for a DSM-IV diagnosis of major depressive disorder with diagnostic specifiers (chronic, without interepisode recovery) or with co-occurring dysthymic disorder indicating a chronic course. The Inventory for Depressive Symptomatology (IDS) Self-Report was used as the primary outcome measure. Mixed-effects linear regression analysis was used to compare the changes on the IDS scores between CBASP and CAU. The IDS was administered before treatment, and after 8, 16, 32 and 52 weeks. Results: At week 52, patients assigned to CBASP had a greater reduction of depressive symptoms compared to patients assigned to CAU (t = -2.00, p = 0.05). However, CBASP and CAU did not differ from each other on the IDS after 8 weeks (t = 0.49, p = 0.63), 16 weeks (t = -0.03, p = 0.98) and 32 weeks (t = -0.17, p = 0.86) of treatment. Conclusions: This trial shows that CBASP is at least as effective as standard evidence-based treatments for chronic depression. In the long run, CBASP appears to have an added effect. © 2014 S. Karger AG, Basel.
    Psychotherapy and Psychosomatics 08/2014; 83(5):263-269. DOI:10.1159/000360795 · 9.37 Impact Factor

Full-text (3 Sources)

Available from
May 21, 2014