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Albert Einstein College of Medicine, Saul R. Korey Department of Neurology, 1165 Morris Park Ave., Room 343, Bronx, NY 10461, USA.
Neurology (Impact Factor: 8.29). 05/2008; 70(18):1594-600. DOI: 10.1212/
Source: PubMed


Characterization of the behavioral correlates of neuromorphometry and neurochemistry in older adults has important implications for an improved understanding of the aging process. The objective of this study was to test the hypothesis that a measure of hippocampal neuronal metabolism was associated with verbal memory in nondemented older adults after controlling for hippocampal volume.
4-T MRI, proton magnetic resonance spectroscopy ((1)H MRS), and neuropsychological assessment were conducted in 48 older adults (23 women; mean age 81 years). Average hippocampal N-acetyl aspartate/creatine ratios (NAA/Cr) and hippocampal volumes were obtained. Neuropsychological evaluation included tests of verbal memory (Buschke and Grober Free and Cued Selective Reminding Test-Immediate Recall [FCSRT-IR], Wechsler Memory Scale-Revised Logical Memory subtest) and attention and executive function (Trail Making Test Parts A and B).
Linear regression analysis indicated that after adjusting for age, hippocampal NAA/Cr was a significant predictor of FCSRT-IR performance (beta = 0.38, p = 0.01, R (2) = 0.21). Hippocampal volume was also a significant predictor of FCSRT-IR performance after adjusting for age and midsagittal area (beta = 0.47, p = 0.01, R (2) = 0.24). In a combined model, hippocampal NAA/Cr (beta = 0.33, p = 0.03) and volume (beta = 0.35, p = 0.03) were independent predictors of FCSRT-IR performance, accounting for 30% of the variance in memory.
These findings indicate that nondemented older adults with smaller hippocampal volumes and lower levels of hippocampal N-acetyl aspartate/creatine ratio metabolites perform more poorly on a test of verbal memory. The integrity of both the structure and metabolism of the hippocampus may underlie verbal memory function in nondemented elderly.

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    • "However, it is still unclear which biological mechanisms contribute to this gender difference in pain perception. The hippocampus plays an important role in a variety of physiological processes including memory, mood and stress (Price and Drevets, 2010; Zimmerman et al., 2008). Many investigators have evaluated the role of the hippocampus in pain processing in human and animal studies (Bingel et al., 2002; Duric and McCarson, 2006; Schweinhardt et al., 2006; Zimmerman et al., 2009). "
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    ABSTRACT: Although previous studies have demonstrated that the hippocampus plays a role in pain processing, the role of hippocampal subfields is uncertain. The goal of this study was to examine the relationship between hippocampal subfield volumes and chronic pain in nondemented older adults. The study sample included 86 community-residing adults age 70 or older who were free of dementia and recruited from the Einstein Aging Study. Chronic pain was defined as pain over the last 3 months, that was moderate or severe (minimum rating of 4 out of 10) most, or all of the time. Hippocampal subfield volumes were estimated using FreeSurfer software. We modeled the association between chronic pain and hippocampal and subfield volume using linear regression. The sample had a mean age of 80 and was 58% female. Chronic pain, present in 55% of the sample, was associated with smaller right and total hippocampal volumes, particularly in women, after adjusting for age, education, and intracranial volume (eTICV). In addition, in women, volume was significantly reduced in participants with chronic pain in right CA2-3 (β=-0.35, p=0.010), right CA4-DG (β=-0.35, p=0.011), left presubiculum (β=-0.29, p=0.030), and left fimbria (β=-0.30, p=0.023). In men, chronic pain was not associated with the volume of any of the hippocampal subfield volumes. Chronic pain in women is associated with a reduction in the volume of right hippocampus and also selected hippocampal subfields. Future studies should clarify the mechanisms underlying the association between regional hippocampal volumes and chronic pain, particularly in women.
    Brain research 07/2014; 2014 July 21(1573):52-64. DOI:10.1016/j.brainres.2014.05.025 · 2.84 Impact Factor
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    • "We have also shown [15] that the FCSRT has a stronger predictive utility for the identification of individuals who will develop dementia over a 2-to 4-year period compared with a widely used test of episodic memory, the Logical Memory subtest of the Wechsler Memory Scale–Revised [16]. The FCSRT is also a strong correlate of neuroimaging and neuropathological markers [17] [18] [19] [20] [21]. "
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    ABSTRACT: This study examined the psychometric relationship between the Word and Picture versions of the Free and Cued Selective Reminding Test (FCSRT) and developed an equation for score conversion. 187 participants were administered the FCSRT-Picture and FCSRT-Word on two visits using a randomized counterbalanced design. Participants had a mean age of 82.1 (sd=5.4) and mean education of 14.5 (sd=3.3) years. Mean FCSRT-Picture Free Recall score (mean 33.0, range: 17-44) was 7.9 points higher than the Word score (mean 25.1, range: 3-43). The Picture and Word FCSRT correlations for Free Recall and Total Recall were r=0.56, p<0.01 and r=0.46, p<0.01, respectively. The Picture and Word versions of the FCSRT were moderately associated in a sample of cognitively normal older adults. The score mean differences and variability between FCSRT-Picture and FCSRT-Word indicate that their scores should not be considered equivalent.
    Alzheimer's and Dementia 07/2012; 8(4):P367. DOI:10.1016/j.jalz.2012.05.1004 · 12.41 Impact Factor
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    • "A large number of studies have found that decreased hippocampal volume is associated with poorer recall of episodic information, including both spatial and verbal material. This association is observed across a number of clinical populations or groups in whom decreased hippocampal volume is notable as compared to control individuals, including nondemented older adults (Zimmerman et al., 2008), and individuals with Alzheimer's disease (Kuczynski et al., 2008), subjective memory deficit (SMD)(Stewart et al., 2008), schizophrenia (Cannon et al., 2005), and developmental amnesia (DA)(Adlam et al., 2005), among others. Conversely, increases in hippocampal volume have been associated with better spatial memory in animals and humans (Jacobs et al., 1990; Sherry et al., 1993; Biegler et al., 2001), most notably in London taxidrivers who show increased hippocampal volume, as compared to control individuals (Maguire et al., 2000). "
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    ABSTRACT: Putative control of encoding and retrieval processes have been linked to communication between the lateral prefrontal cortex (LPFC) and the hippocampus. Moreover, correlations between the LPFC (e.g., MFG) and hippocampus have predicted individuals' ability to inhibit memory retrieval. Anatomically, differences in volume of the hippocampus have been related to changes in long-term episodic memories. Although the relationship between these ideas is clear, few studies have examined the association of how anatomy may affect the role of control over brain regions involved in distint memory processes. The current study sought to examine hippocampal volume and its relationship to LPFC control over the hippocampus. Using an automated cortical/subcortical segmentation technique (FIRST) on brain imaging gata from the Think/No-Think task, we show that hippocampal volume is associated to changes in both enhancement and inhibitory processes of memory retrival.
    Hippocampus 04/2012; 22(4):651-5. DOI:10.1002/hipo.20952 · 4.16 Impact Factor
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