Dam1 complexes go it alone on disassembling microtubules

Department of Biomedical Engineering, University of Minnesota, 312 Church Street SE, 7-132 Hasselmo Hall, Minneapolis, Minnesota 55455, USA.
Nature Cell Biology (Impact Factor: 19.68). 05/2008; 10(4):379-81. DOI: 10.1038/ncb0408-379
Source: PubMed


Kinetochores maintain a mechanical grip on disassembling microtubule plus ends, possibly through a 16-member Dam1 ring that acts as a sliding clamp. It turns out, however, that a ring is not required for maintaining grip: individual Dam1 complexes in vitro can diffuse on the microtubule lattice and track shortening microtubule tips.

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