First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States

JMI Laboratories, North Liberty, IA 52317, USA.
Antimicrobial Agents and Chemotherapy (Impact Factor: 4.45). 07/2008; 52(6):2244-6. DOI: 10.1128/AAC.00231-08
Source: PubMed

ABSTRACT Linezolid resistance has dominantly been mediated by mutations in 23S rRNA or ribosomal protein L4 genes. Recently, cfr has demonstrated the ability to produce a phenotype of resistance to not only oxazolidinones, but also other antimicrobial classes (phenicols, lincosamides, pleuromutilins, and streptogramin A). We describe the first detection of cfr-mediated linezolid resistance in Staphylococcus aureus and Staphylococcus epidermidis recovered from human infection cases monitored during the 2007 LEADER Program.


Available from: Michael Saubolle, May 29, 2015
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