Article

[Treatment of radiation burns with surgery and cell therapy. A report of two cases].

Service de Chirurgie Plastique H.I.A. Percy 100 avenue H. Barbusse 92141 Clamart.
Bulletin de l'Académie nationale de médecine (impact factor: 0.25). 07/2007; 191(6):971-8; discussion 979.
Source: PubMed

ABSTRACT Treatment of severe radiation burns remains a difficult challenge. Conventional surgical treatment (excision, skin grafting, skin or muscle flaps) often fails to prevent unpredictable and uncontrolled extension of the necrotic process. We report two clinical cases in which surgery was combined with mesenchymal stem cell (MSC) therapy. Clinical outcome was good and there was no recurrence of radiation inflammatory waves observed in the first patient after one year. This novel multi-disciplinary therapeutic approach, combining physical techniques, modern plastic surgery and cell therapy should improve the medical management of severe localized radiation burns.

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Keywords

Clinical outcome
 
Conventional surgical treatment
 
medical management
 
mesenchymal
 
modern plastic surgery
 
novel multi-disciplinary therapeutic approach
 
radiation inflammatory waves
 
severe localized radiation burns
 
severe radiation burns
 
skin grafting
 
uncontrolled extension
 

Eric Bey