Antihyperglycemic and antioxidative potential of Matricaria chamomilla L. in streptozotocin-induced diabetic rats.

Department of Chemistry (Biochemistry Division), Faculty of Sciences and Arts, Afyon Kocatepe University, Afyonkarahisar, Turkey.
Journal of Natural Medicines (Impact Factor: 1.52). 08/2008; 62(3):284-93. DOI: 10.1007/s11418-008-0228-1
Source: PubMed

ABSTRACT Plants with antidiabetic activities provide important sources for the development of new drugs in the treatment of diabetes mellitus. In the present study, we investigated possible antihyperglycemic and antioxidative activities of the aerial part of the Matricaria chamomilla L. ethanolic extract (MCE) in streptozotocin (STZ; 70 mg/kg, i.p.)-induced diabetic rats. The following groups were assigned; sham (did not receive any substance), STZ + distilled water (control), STZ + 5 mg/kg glibenclamide, STZ + 20 mg/kg MCE, STZ + 50 mg/kg MCE, STZ + 100 mg/kg MCE. Diabetic rats were treated for 14 days by gavage. Postprandial blood glucose levels, malondialdehyde, reduced glutathione (GSH), nitrate, nitrite, ascorbic acid, retinol, beta-carotene, superoxide dismutase, and catalase levels were measured, and immunohistochemical studies were performed in all of the groups. The obtained data showed that STZ resulted in oxidative stress and affected the antioxidant status. Treatment with different doses of MCE significantly reduced postprandial hyperglycemia and oxidative stress, and augmented the antioxidant system. In histological investigations, MCE treatment protected the majority of the pancreatic islet cells, with respect to the control group. As a result, MCE exhibited significant antihyperglycemic effect and protected beta-cells in STZ-diabetic rats, in a dose-dependent manner, and diminished the hyperglycemia-related oxidative stress.

1 Bookmark
  • [Show abstract] [Hide abstract]
    ABSTRACT: Alzheimer's disease (AD) is clinically characterized by progressive loss of cognitive abilities and usually is accompany with elevated oxidative stress. Chamomile is a plant with antioxidant activity with is currently used in Iranian folk medicine as sedative, analgesic, antipyretic and antispasmodic agent. The present study was investigated the effect of Matricaria chamomilla (MC) on learning and memory functions in scopolamine-induced memory deficit in rats. Memory enhancing activity in scopolamine-induced amnesic rats was investigated by assessing the Morris water maze and passive avoidance paradigm. Forty-two male Wistar rats were divided into 6 equal groups as bellow: 1 – control (received water), 2 – SCOP (received scopolamine 1 mg/kg for 15 days), 3 and 4 – SCOP + MC (received scopolamine and MC extract 200 and 500 mg/kg b.w. per day for 15 days), 5 and 6 – intact groups (received MC extract 200 and 500 mg/kg b.w. per day for 15 days). M. Chamomilla ethanolic extract produced significant memory enhancing activity when evaluated by Morris water maze and passive avoidance paradigm models. Our results suggest that M. chamomilla ethanolic extract has repairing effects on memory deficit and might be beneficial in patients with Alzheimer's disease and behavioral disorders. The memory enhancing activity of the extract may be attributed to the free radical scavenging activity, which would have been afforded by the active constituents present in the extract.
    Biomedicine & Aging Pathology. 08/2014;
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Matricaria recutita, once it has been called as Marticaria chamomilla, Chamomilla recutita, and Chamomilum nobile family Asteraceae. The main constituents of this plant include the terpenoids α-bisabolol and its oxides and azulenes, including chamazulene. Matricaria recutita shows different pharmacological activities like anti-inflammatory, anti-cancer, treatment of stress and depression, anti-allergic etc. This review focuses on the detailed chemical constituents, pharmacological activities of different parts of this plant. INTRODUCTION Matricaria recutita, once it has been called as Marticaria chamomilla, Chamomilla recutita, and Chamomilum nobile family Asteraceae and commonly it is known as German chamomile, Roman chamomile, English chamomile, Camomilla, and Flos Chamomile.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Matricaria recutita L. (Chamomile) has been widely used in the Tunisian traditional medicine for the treatment of digestive system disorders. The present work aims to investigate the protective effects of chamomile decoction extract (CDE) against castor oil-induced diarrhea and oxidative stress in rats. The antidiarrheal activity was evaluated using castor oil-induced diarrhea method. In this respect, rats were divided into six groups: Control, Castor oil, Castor oil+ Loperamide (LOP) and Castor oil+ various doses of CDE. Animals were per orally (p.o.) pre-treated with CDE during one hour and intoxicated for 2 or 4 hours by acute oral administration of castor oil. Our results showed that CDE produced a significant dose-dependent protection against castor oil-induced diarrhea and intestinal fluid accumulation. On the other hand, we showed that diarrhea was accompagned by an oxidative stress status assessed by an increase of malondialdehyde (MDA) level and depletion of antioxidant enzyme activities as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Castor oil also increased gastric and intestinal mucosa hydrogen peroxide (H2O2) and free iron levels. Importantly, we showed that chamomile pre-treatment abrogated all these biochemical alterations. These findings suggested that chamomile extract had a potent antidiarrheal and antioxidant properties in rats confirming their use in traditional medicine.
    Journal of ethnopharmacology 01/2014; · 2.32 Impact Factor

Full-text (2 Sources)

Available from
Jun 3, 2014