Antihyperglycemic and antioxidative potential of Matricaria chamomilla L. in streptozotocin-induced diabetic rats

Department of Chemistry (Biochemistry Division), Faculty of Sciences and Arts, Afyon Kocatepe University, Afyonkarahisar, Turkey.
Journal of Natural Medicines (Impact Factor: 1.59). 08/2008; 62(3):284-93. DOI: 10.1007/s11418-008-0228-1
Source: PubMed


Plants with antidiabetic activities provide important sources for the development of new drugs in the treatment of diabetes mellitus. In the present study, we investigated possible antihyperglycemic and antioxidative activities of the aerial part of the Matricaria chamomilla L. ethanolic extract (MCE) in streptozotocin (STZ; 70 mg/kg, i.p.)-induced diabetic rats. The following groups were assigned; sham (did not receive any substance), STZ + distilled water (control), STZ + 5 mg/kg glibenclamide, STZ + 20 mg/kg MCE, STZ + 50 mg/kg MCE, STZ + 100 mg/kg MCE. Diabetic rats were treated for 14 days by gavage. Postprandial blood glucose levels, malondialdehyde, reduced glutathione (GSH), nitrate, nitrite, ascorbic acid, retinol, beta-carotene, superoxide dismutase, and catalase levels were measured, and immunohistochemical studies were performed in all of the groups. The obtained data showed that STZ resulted in oxidative stress and affected the antioxidant status. Treatment with different doses of MCE significantly reduced postprandial hyperglycemia and oxidative stress, and augmented the antioxidant system. In histological investigations, MCE treatment protected the majority of the pancreatic islet cells, with respect to the control group. As a result, MCE exhibited significant antihyperglycemic effect and protected beta-cells in STZ-diabetic rats, in a dose-dependent manner, and diminished the hyperglycemia-related oxidative stress.

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    • "Cemek et al. investigated the effects of an ethanolic extract of Matricaria chamomilla in streptozotocin (STZ)-induced diabetic rats, and observed significant reductions in blood glucose after 7 to 14 days with 50-100 mg/kg/d extract administered orally [34]. Kato et al. [35] tested instead of ethanolic, hot water chamomile extracts and major constituents in STZ-induced diabetic rats, and they observed decreased hyperglycaemia with 500 mg/kg/d orally applied extract. "
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    PLoS ONE 11/2013; 8(11):e80335. DOI:10.1371/journal.pone.0080335 · 3.23 Impact Factor
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    • "Studies with animal model indicate potent anti-inflammatory action,[5] some anti-mutagenic properties,[6] gastro-protective effect,[7] and anxiolytic effects.[8] Chamomile also has acaricidal effect,[9] anti-microbial activity,[10] anti-viral activity,[11] wound healing activity,[12] and anti-hyperglycemic activity.[3] Anti-proliferative and apoptotic effects were observed too.[13] "
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    • "These reactive compounds can cause peroxidation of lipids, resulting in the formation of hydroperoxy fatty acids and endoperoxides (Pushparaj et al., 2000). Also, Coskun et al. (2005) and Cemek et al. (2008) reported that a considerable necrotic degeneration was observed in the peripheral part of the islets of Langerhans in diabetic rats, Okatomoto (1985) discussed the mechanism of action of STZ by acting as alkylating agent to damage the DNA of the pancreatic beta cell. The author also reported that STZ decomposes to form carbonium ions that alkylate DNA and decrease cellular nicotinamide adenine dinucleotide (NAD) level which may adversely affect the beta cell by interrupting respiratory enzyme activity leading to irreversible cellular necrosis. "
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