Article

Osteoblastic cells: differentiation and trans-differentiation.

Molecular Endocrinology Laboratory (KMEB), Department of Endocrinology, Odense University Hospital & Medical Biotechnology Centre, University of Southern Denmark.
Archives of Biochemistry and Biophysics (impact factor: 2.93). 06/2008; 473(2):183-7. DOI:10.1016/j.abb.2008.03.028 pp.183-7
Source: PubMed

ABSTRACT The osteoblast is the bone forming cell and is derived from mesenchymal stem cells (MSC) present among the bone marrow stroma. MSC are capable of multi-lineage differentiation into mesoderm-type cells such as osteoblasts and adipocytes. Understanding the mechanisms underlying osteoblast differentiation from MSC is a central topic in bone biology that can provide insight into mechanisms of bone maintenance and also novel pharmacological targets to increase osteoblast differentiation and consequently bone formation.

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Keywords

adipocytes
 
bone biology
 
bone formation
 
bone maintenance
 
bone marrow stroma
 
central topic
 
increase osteoblast differentiation
 
mesoderm-type cells
 
MSC
 
multi-lineage differentiation
 
novel pharmacological targets
 
osteoblast
 
osteoblast differentiation
 
osteoblasts