Prognostic Significance of Head-and-Neck Cancer Biomarkers Previously Discovered and Identified Using iTRAQ-Labeling and Multidimensional Liquid Chromatography−Tandem Mass Spectrometry

Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
Journal of Proteome Research (Impact Factor: 4.25). 06/2008; 7(5):2078-87. DOI: 10.1021/pr7007797
Source: PubMed


We describe the prognostic utility of two candidate biomarkers, stratifin and YWHAZ, for head-and-neck/oral squamous cell carcinoma (HNOSCC). To determine the clinical significance of stratifin and YWHAZ in head-and-neck tumorigenesis, the expressions of these two proteins were analyzed in HNOSCCs (51 cases) and nonmalignant tissues (39 cases) using immunohistochemistry. Results suggest the involvement of these proteins in the development of head-and-neck cancer and their association with adverse disease outcome.

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Article: Prognostic Significance of Head-and-Neck Cancer Biomarkers Previously Discovered and Identified Using iTRAQ-Labeling and Multidimensional Liquid Chromatography−Tandem Mass Spectrometry

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    • "14-3-3 proteins have been found to interact with target proteins involved in the regulation of multiple cellular processes, such as cell cycle control, protein trafficking, antiapoptosis , metabolism, signal transduction, inflammation, and cell adhesion/motility (Wilker and Yaffe, 2004; Morrison, 2009). YWHAZ has been identified as a clinically relevant prognostic marker for breast cancer (Lu et al, 2009; Neal et al, 2009), lung cancer (Fan et al, 2007), and head and neck cancer (Matta et al, 2008) and may allow for the identification of patients whose "
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