Article

Lunatic fringe causes expansion and increased neurogenesis of trunk neural tube and neural crest populations.

Division of Biology, 139-74, California Institute of Technology, Pasadena, USA.
Neuron Glia Biology (impact factor: 1.34). 02/2007; 3(2):93-103. DOI:10.1017/S1740925X07000683
Source: PubMed

ABSTRACT Both neurons and glia of the PNS are derived from the neural crest. In this study, we have examined the potential function of lunatic fringe in neural tube and trunk neural crest development by gain-of-function analysis during early stages of nervous system formation. Normally lunatic fringe is expressed in three broad bands within the neural tube, and is most prominent in the dorsal neural tube containing neural crest precursors. Using retrovirally-mediated gene transfer, we find that excess lunatic fringe in the neural tube increases the numbers of neural crest cells in the migratory stream via an apparent increase in cell proliferation. In addition, lunatic fringe augments the numbers of neurons and upregulates Delta-1 expression. The results indicate that, by modulating Notch/Delta signaling, lunatic fringe not only increases cell division of neural crest precursors, but also increases the numbers of neurons in the trunk neural crest.

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Keywords

apparent increase
 
broad bands
 
cell proliferation
 
dorsal neural tube
 
gain-of-function analysis
 
increases
 
migratory stream
 
modulating Notch/Delta signaling
 
nervous system formation
 
neural
 
neural tube
 
neural tube increases
 
neurons
 
potential function
 
precursors
 
prominent
 
retrovirally-mediated gene transfer
 
trunk neural
 
upregulates Delta-1 expression
 

Maria Elena De Bellard