Article

Lamotrigine and catamenial epilepsy.

Department of Neurology, Edith Wolfson Medical Center, Affiliated with Sackler Faculty of Medicine, Tel Aviv University, 58100 Holon, Israel.
Seizure (impact factor: 1.8). 05/2008; 17(6):531-4. DOI:10.1016/j.seizure.2008.02.001 pp.531-4
Source: PubMed

ABSTRACT Catamenial epilepsy (CE) is characterized by epileptic seizures in the female occurring rhythmatically with the menstrual cycle. Hormonal mechanisms have been proposed as a cause of this epileptic form. Few reports about the efficacy of anti-epileptic drugs (AEDs) have been published. We studied prospectively women with CE who were treated with lamotrigine (LTG) for a period of 3 months in order to evaluate its efficacy, measuring the progesterone levels before and after LTG at the same time. LTG seemed to be efficacious in 66% of women, meaning the disappearance of seizures or reduction of 50% or more of the number of seizures. The reported side effects were few and mild, and the drug was well tolerated. Serum progesterone levels were found to rise during LTG treatment.

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Keywords

3 months
 
anti-epileptic drugs
 
Catamenial epilepsy
 
CE
 
disappearance
 
efficacious
 
efficacy
 
epileptic form
 
Hormonal mechanisms
 
lamotrigine
 
LTG treatment
 
menstrual cycle
 
mild
 
progesterone levels
 
prospectively women
 
reported side effects
 
Serum progesterone levels
 

Ronit Gilad