Posttraumatic stress disorder, cognitive function and quality of life in patients with schizophrenia

Schizophrenia Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Psychiatry Research (Impact Factor: 2.47). 06/2008; 159(1-2):140-6. DOI: 10.1016/j.psychres.2007.10.012
Source: PubMed

ABSTRACT The purpose of the present study was to assess posttraumatic stress disorder (PTSD), cognitive function, and quality of life in patients with schizophrenia who had a self-reported history of trauma exposure. Outpatients diagnosed with schizophrenia or schizoaffective disorder were referred to the study. Each patient was assessed with the Positive and Negative Syndrome Scale (PANSS), the Harvard Trauma Questionnaire (HTQ), a cognitive assessment battery, Heinrich's Quality of Life Scale (QLS), and the Behavior and Symptom Identification Scale (BASIS). Eighty-seven subjects who reported experiencing at least one traumatic event were included in the study. Fifteen of 87 (17%) met the DSM-IV criteria for PTSD. The PTSD group had significantly worse overall cognitive performance than the non-PTSD group, especially in the domains of attention, working memory and executive function. In addition, the PTSD group showed significantly worse self-rated quality of life as measured by the BASIS total score. The development of PTSD is associated with poor cognitive function and subjectively, but not objectively, rated low quality of life in patients with schizophrenia. Evaluating PTSD in patients with schizophrenia could have important implications from both clinical and research perspectives.

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    • "While evaluating the health-related impact of natural disasters, special attention must be paid to individuals affected by psychiatric disorders, particularly autism spectrum disorders (ASD). Despite the substantial body of research linking stressful life events to the course of psychiatric diseases such as schizophrenia or affective/mood disorders (Horan et al. 2007; Fan et al. 2008), and the growing body of literature addressing the psychological sequelae of children and adolescents after natural disasters (Roussos et al. 2005; John et al. 2007), the literature completely lacks any descriptions of adaptive outcomes for people with ASD after natural disasters. This offers a special challenge to the scientific community. "
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    ABSTRACT: The literature offers no descriptions of the adaptive outcomes of people with autism spectrum disorder (ASD) after natural disasters. Aim of this study was to evaluate the adaptive behaviour of participants with ASD followed for 1year after their exposure to the 2009 earthquake in L’Aquila (Italy) compared with an unexposed peer group with ASD, by administering the Italian form of the Vineland Adaptive Behaviour Scales (VABS) at baseline, 6months and 1year after the earthquake. Exposed participants declined dramatically in their adaptive behaviour during the first months after the earthquake (p<0.01 for all VABS dimensions). However, immediate intensive post-disaster intervention allowed children and adolescents with autism showing a trend towards partial recovery of adaptive functioning. KeywordsAutism spectrum disorder–Post-traumatic stress disorder–Adaptive behaviour–Post-disaster adaptation–Intensive behavioural intervention–Resiliency
    Journal of Autism and Developmental Disorders 06/2011; 42(6):1-7. DOI:10.1007/s10803-011-1323-9 · 3.34 Impact Factor
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    • "C. Goodman et al. (2007) also reported that survivors of the holocaust who had schizophrenia and comorbid PTSD (n = 14) performed significantly worse than patients with schizophrenia who were not exposed to the holocaust on tests assessing verbal memory, processing speed, and visual scanning. Fan et al. (2008) also recently reported that patients with schizophrenia and PTSD (n = 15) exhibited poorer performance on tests of attention, working memory, and executive functions than did patients with schizophrenia alone. Although having a number of limitations including small numbers of participants , limited evaluation of neurocognitive abilities , reliance on clinical diagnoses of PTSD and schizophrenia, and examination of individuals exposed to trauma who may or may not have developed PTSD, results of these studies (C. "
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    Journal of Clinical and Experimental Neuropsychology 03/2010; 32(7):737-51. DOI:10.1080/13803390903512660 · 2.08 Impact Factor
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