Systemic corticosteroids for acute gout

Transeedijk 62, Lobith, Netherlands, 6915 XZ.
Cochrane database of systematic reviews (Online) (Impact Factor: 6.03). 02/2008; 2(2):CD005521. DOI: 10.1002/14651858.CD005521.pub2
Source: PubMed


This summary of a Cochrane review presents what we know from research about the effect of systemic corticosteroids for acute gout. The review shows that in people with gout: - systemic corticosteroids may slightly improve patients' assessment of pain and disability. However, this could have occurred by chance; - there is no precise information about side effects and complications. Only a minority of the patients treated with the steroid oral prednisolone reported minor side effects. What is gout, and what are systemic corticosteroids? Gout is a sudden, very painful joint inflammation (arthritis). It usually affects the big toe. The inflammation, which is caused by urate crystals, leads to swelling and redness of the joint, and makes it painful to move or even to touch. Systemic corticosteroids are drugs that imitate the corticosteroids that are naturally produced by your own body and may help reduce swelling, redness and pain in joints. Systemic corticosteroids come in a pill form or as an injection given by your doctor.

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  • Article: Gout.
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    ABSTRACT: Gout affects about 5% of men and 1% of women, with up to 80% of people experiencing a recurrent attack within 3 years. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of treatments for acute gout? What are the effects of treatments to prevent gout in people with prior acute episodes? We searched: Medline, Embase, The Cochrane Library, and other important databases up to June 2008 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). We found 21 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. In this systematic review we present information relating to the effectiveness and safety of the following interventions: colchicine, corticosteroids, corticotrophin (ACTH), non-steroidal anti-inflammatory drugs (NSAIDs), sulfinpyrazone, xanthine oxidase inhibitors, advice to lose weight, advice to reduce alcohol intake, advice to reduce dietary intake of purines.
    Clinical evidence 01/2008; 2008.

  • The Lancet 06/2008; 371(9627):1816-8. DOI:10.1016/S0140-6736(08)60775-8 · 45.22 Impact Factor
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