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A twin study investigating the genetic and environmental aetiologies of parent, teacher and child ratings of autistic-like traits and their overlap

Social Genetic and Developmental, Psychiatry (SGDP) Centre, Institute of Psychiatry, De Crespigny Park, London, UK.
European Child & Adolescent Psychiatry (Impact Factor: 3.55). 04/2008; 17(8):473-83. DOI: 10.1007/s00787-008-0689-5
Source: PubMed

ABSTRACT In the present study we investigated phenotypic agreement between informants (parent, teacher and child self-report) on ratings of autistic-like traits and compared the genetic and environmental aetiologies of the informants' ratings and of their covariance. Parents and teachers of >2,500 pairs from a community twin sample completed an abbreviated Childhood Asperger Syndrome Test (CAST). The twins also completed an adapted self-report version of the CAST. Structural equation model-fitting was carried out. Correlations between raters were significant but moderate (0.16-0.33). The magnitude of heritability estimates of autistic-like traits varied across raters, being highest for parent-rated autistic-like traits (82-87%) and more modest for child self-reported autistic-like traits (36-47%). Genetic overlap was significant but moderate across all raters. These findings are discussed in relation to population screening for autism and future genetic research.

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    • "Data from multiple raters may give important additional information and are likely to provide a richer account of autistic-like behaviours. Different raters provide different perspectives on behaviour, which may lead to different heritability estimates [23]. The availability of measures based on additional informants may also reduce rater bias and correlated measurement error. "
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    ABSTRACT: In recent years, several twin studies adopted a dimensional approach to Autism Spectrum Disorders (ASD) and estimated the contribution of genetic and environmental influences to variation in autistic traits. However, no study was performed on adults over 18 years of age and all but two studies were based on parent or teacher ratings. Also, the genetic and environmental contributions to the interplay between autistic traits and adult personality dimensions have not been investigated.
    Comprehensive Psychiatry 12/2014; 58. DOI:10.1016/j.comppsych.2014.12.018 · 2.26 Impact Factor
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    • "Shared environmental influences are environmental influences that are common to both twins and make children growing up in the same family similar. Some studies in middle-to-late childhood report modest shared environmental influences ranging from 10% to 32% [Constantino and Todd, 2000, 2003, 2005; Ronald et al., 2008a], but the majority find no significant effects (see Table II). All studies report moderate influences of the nonshared environment , defined as environmental influences that make children growing up in the same family different, and which by default include measurement error in their term. "
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    • "Lastly, this analysis relied solely on parent-rated autistic traits. Future studies should reinvestigate these questions using trained or multiple raters (Ronald et al. 2008). "
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