Antidepressant activity of fosinopril, ramipril and losartan, but not of lisinopril in depressive paradigms of albino rats and mice

Department of Pharmacology & Pharmacotherapeutics, J.N.Medical College, Belgaum, India.
Indian journal of experimental biology (Impact Factor: 0.84). 04/2008; 46(3):180-4.
Source: PubMed


Fosinopril, ramipril and losartan significantly decreased the duration (sec) of immobility in forced swim test and were comparable to amitriptyline. The duration of immobility were significantly decreased in fosinopril, ramipril and losartan in the tail suspension test and were comparable to amitriptyline. Only losartan significantly increased the rearing number of entries, time spent (sec) in open arm and in light area in comparison to control animals. Fosinopril and ramipril and not lisinopril showed significant antidepressant activity while losartan showed a significant antidepressant and anxiolytic activity. Present findings suggest that these drugs could be better antihypertensives in hypertensive patients with comorbidity like depression or anxiety.

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    • "Cell Mol Neurobiol (Braszko et al. 2003; Germain and Chouinard 1988, 1989). Antidepressant activity of AT1 receptor blockers, including losartan, has been demonstrated only in screening tests for antidepressant activity in naive rats but not in models of depression (Gard et al. 1999; Nayak and Patil 2008; Vijayapandi and Nagappa 2005). Recently, Pedreañez et al. (2011) reported that long-term losartan pretreatment alleviated depressive-like responses of renal oxidative stress in rats induced by repeated FSTs. "
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