Article

The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi.

Department of Genetics, Harvard Medical School, and Department of Molecular Biology, Massachusetts General Hospital, CPZN7250, 185 Cambridge Street, Boston, Massachusetts 02114, USA.
Nature Structural & Molecular Biology (Impact Factor: 11.63). 06/2008; 15(5):531-3. DOI: 10.1038/nsmb.1411
Source: PubMed

ABSTRACT The exonuclease ERI-1 negatively regulates RNA interference in Caenorhabditis elegans and Schizosaccharomyces pombe, and is required for production of some C. elegans endogenous small interfering RNAs. We show that ERI-1 performs 3' end processing of the 5.8S ribosomal RNA in both C. elegans and S. pombe. In C. elegans, two protein isoforms of ERI-1 are localized to the cytoplasm, and each has distinct functions in ribosomal RNA processing and negative regulation of RNA interference.

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