Combined use of phosphodiesterase-5 inhibitors and selective serotonin reuptake inhibitors for temporary ejaculation failure in couple undergoing assisted reproductive technologies

Andrology Unit, Center For Reproductive Medicine, Provincial Hospital, Shandong University, Jinan, Shandong, People's Republic of China.
Fertility and sterility (Impact Factor: 4.59). 05/2008; 91(5):1806-8. DOI: 10.1016/j.fertnstert.2008.03.003
Source: PubMed


To explore the drug treatment for temporary ejaculation failure in couple undergoing assisted reproductive technologies (ART).
Case report.
Andrology unit, center for reproductive medicine. PATIENT (S): Five patients suffering from temporary ejaculation failure during ART.
Assisted reproductive technology. Semen samples were collected by masturbation. The combined use of phosphodiesterase-5 inhibitor (PDE5-I; vardenafil, 10 mg) and selective serotonin reuptake inhibitor (SSRI; sertraline, 50 mg) to treat patients who failed to collect semen on the day of egg retrieval.
Five patients with unexpected ejaculation failure during ART treatments were identified; two patients could not produce spermatozoa 3 h after taking PDE5-I (sildenafil, 50 mg), However, the use of PDE5-I (vardenafil, 10 mg) plus SSRI (sertraline, 50 mg) enabled them to provide spermatozoa successfully. It suggested that the combined protocol could be more efficient for temporary ejaculation failure than sildenafil alone. On the day of the egg retrieval, we directly prescribed vardenafil and sertraline for the other three patients and got sperm samples without difficulty 2 h later.
The results indicate that the combined protocol of vardenafil plus sertraline could resolve the unpredictable ejaculation failure during ART. We presume that it might be helpful for attenuating the patients' stress and anxiety.

25 Reads
  • Source
    • "Evidence also shows that SSRIs have a spermicidal effect in vitro (24). One group has actually described SSRIs as an acutely helpful therapy to improve increased ejaculate volume in men taking Sildenafil (25). While there have been several small trials that link SSRIs to semen abnormalities, the authors could not identify a large trial that definitively link SSRIs to MFI as defined by in ability to achieve pregnancy. "
    [Show abstract] [Hide abstract]
    ABSTRACT: The number of couples seeking consultation for infertility problems has steadily increased over the past decade, affecting 10%-15% of the sexually active population. Abnormal semen production, a male factor infertility (MFI), is thought to be the cause of up to 50% of all infertilities in developed countries. There are potentially many different causes of male infertility, including hormonal, anatomical, and secondary to exposure to exogenous substances. In many cases of MFI, a definitive cause for abnormalities is never identified. Recently, the research community has given greater attention to identifying causes of MFI ranging from genetic Y chromosome microdeletions to mechanisms of environmental damage on sperm production. Still evolving, is a clear understanding of how many pharmaceutical medications may cause MFI, which is often treatable and reversible. In this review we will outline the data regarding various pharmaceutical medications that have been investigated as possible causes of MFI.
    Journal of Reproduction and Infertility 03/2012; 13(1):3-11.
  • [Show abstract] [Hide abstract]
    ABSTRACT: The ion species in the PH<sub>3</sub> and B<sub>2</sub>H<sub>6 </sub> beam extracted from an RF inductively coupled plasma are studied using a magnetic mass spectrometer, SIMS analysis, and TRIM simulation. It shows that the ion beam contains H<sub>x</sub><sup>+</sup> monomer ions, (PH<sub>x</sub><sup>+</sup> or BH<sub>x</sub><sup>+</sup>), and dimers (P<sub>2</sub>H<sub>x</sub><sup>+</sup> or B<sub>2</sub>H<sub>x </sub><sup>+</sup>). The relative percentage of the ion species depends strongly on the RF power applied to the plasma. The percentage of dopant ions also depends on the gas flow rate (ion source chamber pressure) and gas concentration. The impacts of the different ion species on the implantation process are also discussed
    Ion Implantation Technology Proceedings, 1998 International Conference on; 01/2000
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Introduction: The process of IVF can be emotionally and physically stressful on the couples. The male partner is only required to produce semen for insemination with the eggs. Unfortunately, some men are not able to produce semen on the day of oocyte retrieval. Objective: To report five cases of unexpected ejaculation failure on the day of oocyte retrieval. Materials and method: We retrospectively reviewed the case records of five couples over a threeyear period (December 2006-November 2009), who experienced unexpected ejaculation failure on the day of oocyte retrieval for IVF. Data, including age, cause(s) of infertility, previous treatment history and methods adopted to recover sperms were documented. Results: Overall, 301 oocyte retrieval cycles were performed during the three year period. Five men had ejaculatory failure, giving an incidence of 1.66%. Three cases (60%) had no prior history of difficulty in producing semen on demand. Prescription of 50 mg Sildenafil citrate and the couples watching sexually stimulating videos did not remedy the situation. Surgical sperm retrieval was successful in case 1. It yielded no live sperm sample in case 2. Cases 3 and 4 had repeat IVF cycles. The male partners were not aware that oocyte retrieval would take place the next day and produced semen within a couple of hours.
    Middle East Fertility Society Journal 06/2011; 16(2):159-162. DOI:10.1016/j.mefs.2010.12.002
Show more


25 Reads
Available from