Mequinol 2%/tretinoin 0.01% topical solution for the treatment of melasma in men: a case series and review of the literature.
ABSTRACT Melasma is a common hyperpigmentation disorder that typically affects women, though up to 10% of white individuals seeking treatment for melasma are men. Melasma can be a source of embarrassment for men because of its association with women and pregnancy. We performed a case series assessing the use of mequinol 2%/ tretinoin 0.01% topical solution in 5 men with melasma. Four of 5 patients achieved complete clearance of melasma at 12 weeks, and 1 patient showed moderate improvement. Side effects were minimal and consisted of stinging in one patient. All patients maintained results at the 16-week follow-up visit. Mequinol 2%/tretinoin 0.01% topical solution was an effective and well-tolerated treatment of melasma in men. The vehicle resulted in good compliance and minimal adverse effects in patients. This is the first report describing the use of mequinol 2%/tretinoin 0.01% topical solution for the treatment of melasma in men; there are no reports in women.
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ABSTRACT: By midcentury, the U.S.A. will be more ethnically and racially diverse. Skin of colour will soon constitute nearly one-half of the U.S. population, and a full understanding of skin conditions that affect this group is of great importance. Structural and functional differences in the skin, as well as the influence of cultural practices, produce variances in skin disease and presentation based on skin type. In the skin of colour population, dyschromia is a growing concern, and a top chief complaint when patients present to the physician. A thorough understanding of the aetiology and management strategies of facial hyperpigmentation is of importance in caring for those afflicted and also in the development of new therapies.British Journal of Dermatology 10/2013; 169(s3). · 3.76 Impact Factor
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ABSTRACT: Ilaria Ghersetich, Andrea Bassi, Silvia Betti, Piero Campolmi, and Torello Lotti review the literature with regard to treatment options for melasma, as well as offering a scientific background to the condition. Introduction: Melasma is a typical hypermelanosis, and quite a common dermatological skin disease, which involves sun exposed areas of the skin and mostly affects women of reproductive age. Hyperpigmentation is the result of an increase in cutaneous melanin deposition. Method: Different treatment options are currently available for melasma. This article aims to review the literature pertaining to these treatment options to inform evidence-based practice. Discussion: In mixed and epidermal melasma, the increasingly popular combination of chemical peels (especially superficial – 30% salicylic acid and 10% tretinoin mask) with pharmacologic treatment (hydroquinone, azelaic acid, kojic acid) is a good treatment option. In dermal melasma, physical treatments can be considered, such as intense pulsed light therapy (even though only temporary and transient results are achieved in the authors’ experience), or with fractional laser skin resurfacing (fractional photothermolysis), a new approach using vascular lasers for skin rejuvenation. Conclusions: Melasma continues to be a challenge with regard to treatment options. All melasma patients should be made aware that ultraviolet exposure is a significant triggering or aggravating factor in the development of melasma. The choice of treatment in the melasma patient should take into account the type of melasma to be treated, the skin complexion of the patient, and possible previous treatments.Prime. 07/2011; 1(3).
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ABSTRACT: China has the rich bamboo resource, moreover, the species and yield of bamboo both are the first in the world. The extract of bamboo root was often used to cure some intractable diseases in the countryside of China, but the components of bamboo root extract is still unresolved. In order to expedite medicinal application of bamboo root, and to provide further scientific foundation for its top value-added development, pyrolysis- GC/MS technology was used to identify and analyze the top value-added biomedical and bioactive components of benzene/ethanol extract of Moso bamboo root. The extract was pyrolyzed at 750 °C in helium atmosphere, and then the pyrolyzate was analyzed by online-linked GC/MS. Relative content of each component was determined by area normalization. 87 compounds representing 98.31% were identified from 105 peaks. The result showed that the pyrolyzate of benzene/ethanol extract of Moso bamboo root is rich in biomedical components, and also contains some bioactive components which can be used as top value-added materials of high-grade spice, cosmetic, food, and chemical.01/2010;