Antihyperglycemic and hypolipidemic effects ofCostus speciosus in alloxan induced diabetic rats

Department of Biosciences, Sardar Patel University, Vallabh Vidyanagar-388120, Gujarat, India.
Phytotherapy Research (Impact Factor: 2.66). 05/2008; 22(5):620-6. DOI: 10.1002/ptr.2302
Source: PubMed


Hyperglycemia, abnormal lipid and antioxidant profiles are the most usual complications in diabetes mellitus. In the present study, the antihyperglycemic, antihyperlipemic and antioxidant potency of an ethanol extract of Costus speciosus root was investigated in alloxan-induced diabetic male (Charles Foster) rats. Four groups of alloxan diabetic rats (n = 6) were administered orally with different doses of Costus speciosus root extract (150, 300 and 450 mg/kg BW) and a standard drug, glibenclamide (600 microg/kg BW), for 4 weeks. Two groups of rats (n = 6) served as normal and diabetic controls. While the diabetic controls showed significant abnormal carbohydrate, lipid and antioxidant profiles, administration of 150 mg/kg BW dose neither improved glucose nor lipid metabolism and antioxidant levels. Administration of 300 and 450 mg/kg BW doses, however, resulted in a reversal of diabetes and its complications. Both doses significantly brought down blood glucose concentration (26.76%, 34.68%), increased glycogenesis and decreased glyconeogenesis bringing the glucose metabolism toward normalcy. These doses also reversed the hyperlipidemia by reducing plasma total lipid (12.87%, 178.24%), cholesterol (21.92%, 30.77%) and triglyceride (25.32%, 33.99%) and improved hepatic antioxidant enzyme activities. The high dose (450 mg/kg BW) was found to have more potential antioxidant activities compared with glibenclamide. It is concluded that Costus speciosus root extract possesses anti-hyperglycemic, antihyperlipemic and antioxidative effects, which may prove to be of clinical importance in the management of diabetes and its complications.

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    • "The species has been validated for certain pharmacological activities namely; antidiabetic and hypolipidemic activity and in the treatment of bronchial asthma [3] [4] [5] [6] , anticholinesterase activity [7] , hepatoprotective activity [8] , antioxidant activity [9] [10] , antibacterial activity, antifungal activity [11] , antifertility activity [12] and spasmolytic activity. "
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    ABSTRACT: To evaluate the diagnostic pharmacognostical characters of Costus speciosus (aerial parts) along with their physico-chemical parameters and fluorosence analysis.
    Asian Pacific Journal of Tropical Biomedicine 06/2014;
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    • "Areal parts of this plant had been tested to reduce fever and to treat mental disorder [11]. Rhizome and root (extracts) have been extensively studied for numerous medicinal properties including antidiabetic [12], hypolipidemic [12], anticholinesterase, hepatoprotective, antistress, antioxidant, antibacterial, antifertility, anti-inflammatory, and antipyretic properties (Srivastava et al., 2011). "
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    ABSTRACT: Costus speciosus is a medicinal plant commonly known as wild ginger distributed in South and Southeast Asian countries. Leaves of this plant are used for ayurvedic treatment regimes in malignancies and mental illness. Rhizome extract from the plant is used to treat malignancies, pneumonia, urinary disorders, jaundice, rheumatism, and diabetes. The goal of this study was to investigate the effects of methanol extract of leaves of C. speciosus on the growth of human hepatocellular carcinoma (HepG2) cells and understand possible mechanisms of its action. Viability of HepG2 cells were measured by MTS assay after 24 h and 48 h treatment with extracts of 1, 10, 50, 100, and 200 μ g/mL concentrations. Cell cycle analysis and apoptosis were evaluated by flow cytometry and caspase-3 induction. HepG2 cells treated with 100 μ g/mL methanol leaf extract for 24 h displayed a significant reduction in cell viability (P ≤ 0.05). The methanol extract perturbed cell cycle progression, modulated cell cycle and regulated, signal molecules were involved in induction of apoptosis in HepG2 cells. Our findings indicate that phytochemicals of leaves of C. speciosus shows potential for natural therapeutic product development for hepatocellular carcinoma. This is the first report to demonstrate in vitro anticancer activity of leaf extract of C. speciosus in relation to liver cancer.
    04/2014; 2014(4):637098. DOI:10.1155/2014/637098
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    • "C. speciosus supplementation has a healthy effect on liver and kidney functions. Bavarva and Narasimhacharya (2008) reported that the diabetic control group exhibited significantly higher amounts of urea and creatinine while the ethanolic extract of C. speciosus administered diabetic rats registered significantly lowered urea and creatinine serum level. Other herbs from Zingiberaceae family as Zingiber officinale is a useful agent for the prevention of renal ischemia reperfusion-induced injuries (Maghsoudi et al., 2011) and carbon tetrachloride renal induced injuries (Hamed et al., 2012). "
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    ABSTRACT: Sixty Egyptian buffalo heifers ageing about one year old, with an average weight of about 250 to 260 kg were allotted randomly according to their live body weight and age into three equal groups; Group I which received a basal ration; Group II which received a basal ration with fine ground Costus speciosus roots in a concentration of 2.5 kg/ton ration and Group III which received a basal ration with fine ground C. speciosus roots in a concentration of 5 kg/ton ration. Blood samples were collected from each group and divided into two blood samples, one for serum separation and the other for hematological study. Separated serum samples were subjected to the biochemical analysis of glucose, cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, urea, uric acid and electrophoretic pattern. The obtained data revealed a decrease in serum glucose and cholesterol levels which may be utilized in anabolic pathways during this period. While total protein, albumin, α 1 -globulin, β-globulin, hemoglobin, packed cell volume (PCV) and lymphocytes were significantly increased especially in Group III. In addition, the erythrocytes antioxidant status was significantly improved by C. speciosus supplementation. We could conclude that supplementation of C. speciosus powder to the Egyptian buffalo heifers improves the health status, total antioxidant capacity and hematology. So, we advise owners to add C. speciosus ground powder to the ration of heifers.
    African journal of pharmacy and pharmacology 11/2013; 7(42):2774-2779. DOI:10.5897/AJPP2013.3519 · 0.84 Impact Factor
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