Antihyperglycemic and hypolipidemic effects ofCostus speciosus in alloxan induced diabetic rats

Department of Biosciences, Sardar Patel University, Vallabh Vidyanagar-388120, Gujarat, India.
Phytotherapy Research (Impact Factor: 2.4). 05/2008; 22(5):620-6. DOI: 10.1002/ptr.2302
Source: PubMed

ABSTRACT Hyperglycemia, abnormal lipid and antioxidant profiles are the most usual complications in diabetes mellitus. In the present study, the antihyperglycemic, antihyperlipemic and antioxidant potency of an ethanol extract of Costus speciosus root was investigated in alloxan-induced diabetic male (Charles Foster) rats. Four groups of alloxan diabetic rats (n = 6) were administered orally with different doses of Costus speciosus root extract (150, 300 and 450 mg/kg BW) and a standard drug, glibenclamide (600 microg/kg BW), for 4 weeks. Two groups of rats (n = 6) served as normal and diabetic controls. While the diabetic controls showed significant abnormal carbohydrate, lipid and antioxidant profiles, administration of 150 mg/kg BW dose neither improved glucose nor lipid metabolism and antioxidant levels. Administration of 300 and 450 mg/kg BW doses, however, resulted in a reversal of diabetes and its complications. Both doses significantly brought down blood glucose concentration (26.76%, 34.68%), increased glycogenesis and decreased glyconeogenesis bringing the glucose metabolism toward normalcy. These doses also reversed the hyperlipidemia by reducing plasma total lipid (12.87%, 178.24%), cholesterol (21.92%, 30.77%) and triglyceride (25.32%, 33.99%) and improved hepatic antioxidant enzyme activities. The high dose (450 mg/kg BW) was found to have more potential antioxidant activities compared with glibenclamide. It is concluded that Costus speciosus root extract possesses anti-hyperglycemic, antihyperlipemic and antioxidative effects, which may prove to be of clinical importance in the management of diabetes and its complications.

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    • "The species has been validated for certain pharmacological activities namely; antidiabetic and hypolipidemic activity and in the treatment of bronchial asthma [3] [4] [5] [6] , anticholinesterase activity [7] , hepatoprotective activity [8] , antioxidant activity [9] [10] , antibacterial activity, antifungal activity [11] , antifertility activity [12] and spasmolytic activity. "
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    ABSTRACT: To evaluate the diagnostic pharmacognostical characters of Costus speciosus (aerial parts) along with their physico-chemical parameters and fluorosence analysis.
    Asian Pacific Journal of Tropical Biomedicine 06/2014;
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    • "C. speciosus supplementation has a healthy effect on liver and kidney functions. Bavarva and Narasimhacharya (2008) reported that the diabetic control group exhibited significantly higher amounts of urea and creatinine while the ethanolic extract of C. speciosus administered diabetic rats registered significantly lowered urea and creatinine serum level. Other herbs from Zingiberaceae family as Zingiber officinale is a useful agent for the prevention of renal ischemia reperfusion-induced injuries (Maghsoudi et al., 2011) and carbon tetrachloride renal induced injuries (Hamed et al., 2012). "
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    ABSTRACT: Sixty Egyptian buffalo heifers ageing about one year old, with an average weight of about 250 to 260 kg were allotted randomly according to their live body weight and age into three equal groups; Group I which received a basal ration; Group II which received a basal ration with fine ground Costus speciosus roots in a concentration of 2.5 kg/ton ration and Group III which received a basal ration with fine ground C. speciosus roots in a concentration of 5 kg/ton ration. Blood samples were collected from each group and divided into two blood samples, one for serum separation and the other for hematological study. Separated serum samples were subjected to the biochemical analysis of glucose, cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, urea, uric acid and electrophoretic pattern. The obtained data revealed a decrease in serum glucose and cholesterol levels which may be utilized in anabolic pathways during this period. While total protein, albumin, α 1 -globulin, β-globulin, hemoglobin, packed cell volume (PCV) and lymphocytes were significantly increased especially in Group III. In addition, the erythrocytes antioxidant status was significantly improved by C. speciosus supplementation. We could conclude that supplementation of C. speciosus powder to the Egyptian buffalo heifers improves the health status, total antioxidant capacity and hematology. So, we advise owners to add C. speciosus ground powder to the ration of heifers.
    African journal of pharmacy and pharmacology 11/2013; 7:2774-2779. DOI:10.5897/AJPP2013.3519 · 0.84 Impact Factor
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    • "Costunolide isolated from the plant significantly decreases HbA1c, serum total cholesterol, triglyceride, LDL-cholesterol and at the same time increases plasma insulin, tissue glycogen, HDL-cholesterol and serum protein (Eliza et al. 2009). Bavarva and Narasimhacharya, (2008) had found rhizome extract reverse diabeties and its complications; the extract is also found to improve hepatic antioxidant enzyme activity acting on neurotransmitters and monoamine oxidase activity (Varma and Khosa, 2009a). Binny et al. (2010) proved anti-inflammatory and antipyretic properties of the rhizome; they also possess significant hepatoprotective activity against carbontetrachloride induced hepatotoxicty (Varma and Khosa, 2009b). "
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    ABSTRACT: Ayurveda plays an important role in the life of people from India for health and longevity. The study of plants used in the ayurvedic preparations always encourages undertaking new aspect of study. Costus speciosus (Koenig ex Retz.) Smith, commonly known as 'Keyu' or 'Kust' is ayurvedic drug plant of repute used to treat various ailments. It is also used in folk medicine in various parts of India. All plant parts are used as medicine. Though an important medicinal plant, no anatomical data is available for drug characterization. Drug characterization is important to understand purity of the drug. Here an attempt is made to study the macro and micromorphology of all plant organs in details. Flowers are characterized by presence of eye shaped nectaries on bracts and multicellular, yellow coloured juicy trichomes on petaloid stamen; anatomically also several characteristic features are exhibited by plant which are unique to the species. Stomatal index significantly vary at upper (5.58%) and lower epidermis (10.59%), respectively.
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