Omega-3/Omega-6 Fatty Acids for Attention Deficit Hyperactivity Disorder

Department of Child and Adolescent Psychiatry, Göteborg University, Göteborg, Sweden.
Journal of Attention Disorders (Impact Factor: 3.78). 05/2008; 12(5):394-401. DOI: 10.1177/1087054708316261
Source: PubMed


The aim of the study was to assess omega 3/6 fatty acids (eye q) in attention deficit hyperactivity disorder (ADHD).
The study included a randomized, 3-month, omega 3/6 placebo-controlled, one-way crossover trial with 75 children and adolescents (8-18 years), followed by 3 months with omega 3/6 for all. Investigator-rated ADHD Rating Scale-IV and Clinical Global Impression (CGI) scale were outcome measures.
A majority did not respond to omega 3/6 treatment. However, a subgroup of 26% responded with more than 25% reduction of ADHD symptoms and a drop of CGI scores to the near-normal range. After 6 months, 47% of all showed such improvement. Responders tended to have ADHD inattentive subtype and comorbid neurodevelopmental disorders.
A subgroup of children and adolescents with ADHD, characterized by inattention and associated neurodevelopmental disorders, treated with omega 3/6 fatty acids for 6 months responded with meaningful reduction of ADHD symptoms.

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    • "Even though researchers have shown that there is a significant relationship between omega-3 fatty acids deficiency and ADHD symptoms,[1417263233] and omega-3 supplements have been capable to get an optimal plasma level in these patients,[192034] there is a lot of debate about their effectiveness to reduce ADHD symptoms. Review studies have generally stated that open-label researches showed improvement of ADHD symptom by omega-3 supplements, but randomized controlled trials were often unsuccessful.[252635] Inattentive subtypes of ADHD, patients with neuro developmental co morbidities, long term combination therapy of omega-3 and omega-6 fatty acids and simultaneously use of essential vitamins and minerals have tend to be more successful.[2025343536] "
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    ABSTRACT: Although most of the ADHD (Attention Deficit Hyperactivity Disorder) patients respond to stimulant drugs very well, alternative drugs are required for non respondents. It has been revealed that subgroups of patients with ADHD have omega-3 fatty acid deficiency. So, the present study was planned to illustrate the effect of omega-3 supplementation, as an add-on to methylphenidate, on ADHD patients. In this double-blind RCT, ADHD children without any co morbidity, who had been diagnosed by a child and adolescent psychiatrist in child and adolescent university clinic, participated and were randomly divided into 2 groups. The experimental group methylphenidate plus omega-3 capsule (2000mg/d), while control group took methylphenidate plus placebo. Severity of ADHD symptoms were assessed by ADHD rating scale at the baseline and after 2, 4 and 8 weeks of treatment. 69 patients (experimental = 36, control = 33) aged 7 to 15 participated. A significant reduction of both parent's and teacher's ADHD rating scale scores in both groups was observed. Bu t it couldn't show any difference between two groups. Difference score of parent's at baseline was 1.86+- (5/40), Pv 0.262, after 2 weeks -.70+- (4/30), Pv 0.668,4 weeks. 19+- (5/60), Pv 0.902 and 8 weeks. 30+- (4/42), Pv 0.845. Difference score of Teacher's at baseline was -1.56+- (3/45), Pv 0.541, after 2 weeks -.46+- (6/24), Pv 0.888, 4 weeks. 45+- (5/41), 0.868 and 8 weeks. 73+- (4/18), Pv 0.748. Omega-3 did not enhance the therapeutic results of methylphenidate in ADHD patients.
    Journal of research in medical sciences 08/2013; 18(8):653-8. · 0.65 Impact Factor
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    • "There are also too few trials which employ similar designs which make cross-study comparisons difficult. In support of evidence for LC-PUFA insufficiency in children with ADHD, several n−3/6 supplementation trials have reported some improvement in ADHD symptoms compared to placebo [16] [17] [18]. This was recently confirmed in a meta-analysis of 10 supplementation trials which included 699 children with ADHD [19]. "
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    ABSTRACT: A number of research studies have reported abnormal plasma fatty acid profiles in children with ADHD along with some benefit of n-3 to symptoms of ADHD. However, it is currently unclear whether (lower) long chain-polyunsaturated fatty acids (LC-PUFAs) are related to ADHD pathology or to associated behaviours. The aim of this study was to test whether (1) ADHD children have abnormal plasma LC-PUFA levels and (2) ADHD symptoms and associated behaviours are correlated with LC-PUFA levels. Seventy-two, male children with (n=29) and without a clinical diagnosis of ADHD (n=43) were compared in their plasma levels of LC-PUFA. Plasma DHA was higher in the control group prior to statistical correction. Callous-unemotional (CU) traits were found to be significantly negatively related to both eicosapentaenoic acid (EPA), and total omega-3 in the ADHD group. The findings unveil for the first time that CU and anti-social traits in ADHD are associated with lower omega-3 levels.
    Prostaglandins Leukotrienes and Essential Fatty Acids 05/2013; 88(6). DOI:10.1016/j.plefa.2013.03.009 · 2.35 Impact Factor
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    • "A survey of the available literature suggests that nutritional and dietary interventions are considered routine treatment for developmental disorders including autism [1] [2]. However, the study and implementation of such measures have been limited to the industrialized and affluent countries of North America and Western Europe, with few exceptions [3] [4]. "
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    ABSTRACT: Objective: Arab populations lack data related to nutritional assessment in children with autism spectrum disorders (ASDs), especially micronutrient deficiencies such as folate and vitamin B12. Methods: To assess the dietary and serum folate and vitamin B12 statuses, a hospital-based case-control study was conducted in 80 Omani children (40 children with ASDs versus 40 controls). Results: The ASD cases showed significantly lower levels of folate, vitamin B12, and related parameters in dietary intake and serum levels. Conclusion: These data showed that Omani children with ASDs exhibit significant deficiencies in folate and vitamin B12 and call for increasing efforts to ensure sufficient intakes of essential nutrients by children with ASDs to minimize or reverse any ongoing impact of nutrient deficiencies.
    Nutrition 12/2012; 29(3). DOI:10.1016/j.nut.2012.09.014 · 2.93 Impact Factor
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