Article

Regression, Developmental Trajectory and Associated Problems in Disorders in the Autism Spectrum: The SNAP Study

Newcomen Centre, Guy's & St. Thomas' NHS Foundation Trust, London, SE1 9RT, UK.
Journal of Autism and Developmental Disorders (Impact Factor: 3.34). 06/2008; 38(10):1827-36. DOI: 10.1007/s10803-008-0571-9
Source: PubMed

ABSTRACT We report rates of regression and associated findings in a population derived group of 255 children aged 9-14 years, participating in a prevalence study of autism spectrum disorders (ASD); 53 with narrowly defined autism, 105 with broader ASD and 97 with non-ASD neurodevelopmental problems, drawn from those with special educational needs within a population of 56,946 children. Language regression was reported in 30% with narrowly defined autism, 8% with broader ASD and less than 3% with developmental problems without ASD. A smaller group of children were identified who underwent a less clear setback. Regression was associated with higher rates of autistic symptoms and a deviation in developmental trajectory. Regression was not associated with epilepsy or gastrointestinal problems.

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