Primary solitary fibrous tumor (SFT) in the retroperitoneum

Department of Regenerative and Transplant Medicine, Division of Urology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Urologic Oncology (Impact Factor: 3.36). 05/2008; 26(3):254-9. DOI: 10.1016/j.urolonc.2007.03.024
Source: PubMed

ABSTRACT Solitary fibrous tumor (SFT) is an infrequent but distinct neoplasm, which generally arises from submesothelial connective tissue in the pleura. SFT is rarely recognized in extrathoracic sites, and histologically identical conditions have also been reported in the retroperitoneum, although their pathophysiology has not been extensively investigated.
We present four cases of primary SFT in the retroperitoneum, and review 37 similar cases in the previous literature.
About 40% of patients were asymptomatic, and 19.2% and 15.4% presented with an abdominal mass and urinary symptoms, respectively. The tumor size ranged between 2 and 26 (mean 9.1) cm. Sixty-three percent of tumors showed nonspecific development with haphazard distribution of bland short spindle or polygonal cells with or without collagenous bundles and stromal hyalinization. In 22.0%, hemangiopericytomatous appearance was seen. About 15% of cases showed histologically malignant characteristics. The tumor cells were immunoreactive for vimentin in all cases, CD34 in 91% and Bcl-2 in 86%. All tumors were excised, and in 85.4% of cases, tumors did not recur postoperatively for 6 to 48 months. No significant difference was found between the recurrence rate of histologically benign and malignant cases. Cases positive for both CD34 and Bcl-2 had no recurrence.
The identification of SFT in the retroperitoneum is of importance because histopathological indicators of malignancy are not necessarily associated with clinical malignant potential in many cases of retroperitoneal SFT. Retroperitoneal SFT showing typical pathological features with expression of CD34 and Bcl-2 is associated with a favorable outcome following excision.

  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: This work presented the design and analysis of a wide-band low noise transimpedance amplifier (TIA) with broader bandwidth for fiber optic communication. Related formulae for the TIA are derived. The circuit is simulated in TSMC 0.25μm process. Additional program is compiled to simulate the circuit gain and phase frequency responses.
    Microwave and Millimeter Wave Technology, 2004. ICMMT 4th International Conference on, Proceedings; 09/2004
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Solitary fibrous tumors are rare spindle cell neoplasms usually arising in the pleura. They have, however, also been reported at extrapleural locations. Solitary fibrous tumor (SFT) of the kidney is rare. Despite its rarity, histological diagnosis of solitary fibrous tumor is crucial to avoid misdiagnosis with other more aggressive tumors arising in the kidney. We report a solitary fibrous tumor of the left kidney that presented as a malignant tumor in a 51-year-old woman, and include clinical and radiographic findings. The tumor was well circumscribed and composed of spindle cells in a collagenous stroma. Immunohistochemistry showed reactivity for vimentin, CD 34, BCL-2 protein and CD99. Immunohistochemical stains for cytokeratin, S-100, desmin, alpha-smooth muscle actin and HMB-45 were negative. A diagnosis of SFT was made based on light microscopy and immunohistochemistry.
    Apmis 04/2007; 115(3):259-62. DOI:10.1111/j.1600-0463.2007.apm_500.x
  • [Show abstract] [Hide abstract]
    ABSTRACT: Solitary fibrous tumor is a distinct neoplasm, rarely recognized in extrathoracic sites. The article reports a new case in the retroperitoneum in a 55 year-old man, who presented with urinary symptoms. Tumor was completely excised, and the solitary fibrous tumor was diagnosed after pathologic examination and immunohistochemistry. The patient has remained free of disease for five years since surgery. An uncommon variant of retroperitoneal solitary fibrous tumor with giant multinucleated cells was documented in the study.
    10/2009; 1(5):285-7.