Cerebrovascular risk factors and incident depression in community-dwelling elderly

Department of Epidemiology & Biostatistics, Erasmus Medical Center, Rotterdam, the Netherlands.
Acta Psychiatrica Scandinavica (Impact Factor: 5.61). 04/2008; 118(2):139-48. DOI: 10.1111/j.1600-0447.2008.01189.x
Source: PubMed


The 'vascular depression' hypothesis suggests that late-life depression results from vascular brain damage. We studied the longitudinal association between cerebrovascular risk factors and incident depression in a large population-based study.
Two thousand nine hundred and thirty-one persons with the age of > or =61 years were followed up. Data on a comprehensive set of cerebrovascular risk factors were collected at baseline. Participants received a psychiatric assessment 5 years later to establish DSM-IV diagnoses.
Only current smoking and antihypertensive drug use were independently associated with incident depressive symptoms. Diabetes mellitus and the Framingham stroke risk score were related to incident depressive disorder. No relation with depression was observed for cholesterol, diastolic and systolic blood pressure, history of cardiovascular disease, atrial fibrillation, left ventricular hypertrophy or the use of statins and anticoagulants.
These results moderately support the 'vascular depression' hypothesis.

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    • "Although it is assumed that antidepressant use may mask the longitudinal relationship between depression and diabetes, studies that examined the association of antidepressant use and diabetes were also included (Egberts et al. 1997; Kivimaki et al. 2010; Knol et al. 2009; Luijendijk et al. 2008). Of these, two studies (Egberts et al. 1997; Luijendijk et al. 2008) used the same data, and only the most recent study by Luijendijk et al. was retained. "
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    • "Four studies (735,143 participants) reported on depression and suicidal behavior [17,70,94]. No evidence of increased risk was seen for these endpoints (OR = 0.83; 95% CI 0.50 to 1.39) and this result was consistent across sub-groups. "
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    BMC Medicine 03/2014; 12(1):51. DOI:10.1186/1741-7015-12-51 · 7.25 Impact Factor
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    Depression and Diabetes, 1. edited by Wayne Katon, Mario Maj, Norman Sartorius, 08/2010: chapter 1: pages 1 - 27; Wiley-Blackwell., ISBN: 9780470667309
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