Article

Pattern of macular thickness changes measured by ocular coherence tomography in patients with multiple sclerosis.

Outpatient Neurology Clinic, University Hospital Basel, Basel, Switzerland.
Klinische Monatsblätter für Augenheilkunde (impact factor: 0.51). 06/2008; 225(5):408-12. DOI:10.1055/s-2008-1027253 pp.408-12
Source: PubMed

ABSTRACT An analysis of the pattern of retinal thickness changes in macula in patients with multiple sclerosis (MS) was performed.
In fifteen patients with MS retinal thickness measurements in the central (fovea plus inner macular ring) and peripheral (outer ring) macula obtained by ocular coherence tomography (OCT-3 device) were compared to those of 15 age-matched healthy controls.
Eyes of MS patients had on the average a thinner macula (241.8 +/- 20.6 micrometers) than control eyes (252.0 +/- 16.4, p value 0.038). Significant segmental differences occurred in the central macula (p = 0.013). Eight eyes with a positive history of optic neuritis (ON) had on average a thinner macula (226.8 +/- 14.0) than eyes of MS patients without a history of ON (non-ON eyes: 247.3 +/- 20.1, p value 0.01). The only measure significantly different between non-ON and control eyes was the ratio between the central and peripheral macular thickness (p = 0.017). Average macular thickness in non-ON eyes, unlike control eyes (r = - 0.63, p = 0.0002), did not correlate with age (r = 0.01, p = 0.97), however, it did show a borderline correlation with disease duration (r = - 0.41, p = 0.056).
Preferential thinning in the central relative to the peripheral macular region is present in eyes of patients with MS. The macular thickness pattern is likely due to the histological distribution of nerve fibre layer and retinal ganglion cell in the macular area and seems to be particularly informative of neurodegeneration in the eyes of MS patients without a history of optic neuritis.

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Keywords

borderline correlation
 
control eyes
 
eyes
 
histological distribution
 
inner macular ring
 
macular area
 
macular thickness pattern
 
MS patients
 
MS retinal thickness measurements
 
multiple sclerosis
 
nerve fibre layer
 
non-ON eyes
 
OCT-3 device
 
ocular coherence tomography
 
outer ring
 
peripheral macular region
 
peripheral macular thickness
 
positive history
 
retinal ganglion cell
 
retinal thickness changes