Article

Silybin treatment is associated with reduction in serum ferritin in patients with chronic hepatitis C

Department of Medicine, University of Washington Medical Center, Seattle, WA, USA.
Journal of clinical gastroenterology (Impact Factor: 3.19). 08/2008; 42(8):937-44. DOI: 10.1097/MCG.0b013e31815cff36
Source: PubMed

ABSTRACT The goal of this study was to examine the effect of a standardized silybin and soy phosphatidylcholine complex (IdB 1016) on serum markers of iron status.
Milk thistle and its components are widely used as an alternative therapy for liver disease because of purported antioxidant, anti-inflammatory, and iron chelating properties.
Thirty-seven patients with chronic hepatitis C and Batts-Ludwig fibrosis stage II, III, or IV were randomized to 1 of 3 doses of IdB 1016 for 12 weeks. Serum ferritin, serum iron, total iron binding capacity, and transferrin-iron saturation were measured at baseline, during treatment, and 4 weeks thereafter. Wilcoxon signed rank tests were used to compare baseline and posttreatment values.
There was a significant decrease in serum ferritin from baseline to end of treatment (mean, 244 vs. 215 mug/L; median, 178 vs. 148 mug/L; P=0.0005); 78% of subjects had a decrease in serum ferritin level. There was no significant change in serum iron or transferrin-iron saturation. Multivariate logistic regression analysis in a model that included dose, age, sex, HFE genotype, history of alcohol use, and elevated baseline ferritin levels demonstrated that stage III or IV fibrosis was independently associated with decreased posttreatment serum ferritin level.
Treatment with IdB 1016 is associated with reduced body iron stores, especially among patients with advanced fibrosis stage.

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    • "In contrast, silybin resulted in a significant reduction in the amount of iron absorbed from a single meal, even in the presence of ascorbic acid. A published study reported that the iron-chelating properties of silybin were responsible for a decrease in body iron stores in patients with chronic hepatitis C who had been taking silybin orally for 12 weeks (Bares et al., 2008), which supports the outcome of our study. Likewise, silybin in conjunction with desferrioxamine may be a more effective means of reducing iron stores in patients with β-thalassaemia, compared with desferrioxamine alone (Gharagozloo et al., 2009). "
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