Article

Eosinophilic cholangiopathy with concurrent eosinophilic colitis in a patient with idiopathic hypereosinophilic syndrome.

Division of Gastroenterology, University of Miami Leonard M. Miller School of Medicine, Miami, Florida 33136, USA.
European Journal of Gastroenterology & Hepatology (Impact Factor: 2.15). 07/2008; 20(6):574-7. DOI: 10.1097/MEG.0b013e3282f1cc11
Source: PubMed

ABSTRACT Eosinophilic cholangiopathy is a rare cholestatic disorder of unknown etiology. Simultaneous histologic documentation of eosinophilic involvement of the bile ducts and gastrointestinal tract has been reported previously in only a few well-documented cases. We report a 52-year-old man with a history of idiopathic hypereosinophilic syndrome who presented with acute diarrhea and cholestatic hepatitis. Colonoscopy revealed colitis, and a biopsy showed eosinophilic infiltrates in the colonic mucosa. Liver biopsy showed dense eosinophilic inflammation in the portal areas with bile duct damage. This case demonstrates the entity of hepatic involvement in idiopathic hypereosinophilic syndrome and the difficulties related to diagnosis and treatment.

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