The release behavior of doxorubicin hydrochloride from medicated fibers prepared by emulsion-electrospinning.
ABSTRACT The release behavior of a water-soluble small molecule drug from the drug-loaded nanofibers prepared by emulsion-electrospinning was investigated. Doxorubicin hydrochloride (Dox), a water-soluble anticancer agent, was used as the model drug. The laser scanning confocal microscopic images indicated that the drug was well incorporated into amphiphilic poly(ethylene glycol)-poly(L-lactic acid) (PEG-PLA) diblock copolymer nanofibers, forming "core-sheath" structured drug-loaded nanofibers. The drug release behavior of this drug-loaded system showed a three-stage diffusion-controlled mechanism, in which the release rate of the first stage was slower than that of the second stage, but both obeyed Fick's second law. Based on these results, it is concluded that the Dox-loaded fibers prepared by emulsion-electrospinning represent a reservoir-type delivery system in which the Dox release rate decreases with the increasing Dox content in the fibers.
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ABSTRACT: The nanofibers fabricated by using an electrohydrodynamic process has been used as various applications, such as nano-device, filtering system, protective clothes, wound dressing, and drug delivery system (DDS). Of these applications, the DDS should be needed to minimize side effects of drugs, maximize the properties of medicine, and efficiently deliver the required amount of drugs to the diseased area. In this paper, by using the electro spinning process, which is one of electrohydrodynamic processes, two different types, polycarprolactone and poly(ethylene oxide)/Rhodamine B, of electrospun mats were fabricated layer by layer and the release behavior of Rhodamine B was characterized with time. In addition, to show the feasibility of DDS of this type, we tested release behavior of a peptide of the nanofiber system, a PCL/(Peptide+PEO)/PCL nanofiber mat. The released peptide did not loss biological activities. From these results, we believe that the layered nanofiber mat as a DDS has enough function of a new drug delivery system.Polymer Korea 01/2009; 33(3). · 0.43 Impact Factor
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ABSTRACT: The purpose of this study was to evaluate both cytotoxicity in vitro and in vivo anticancer activities of implantable doxorubicin hydrocloride (Dox)-loaded diblock copolymer poly(ethylene glycol)-b-poly(L-lactic acid) (PEG-PLA) fiber mats (hereafter medicated mats). For in vitro evaluation, SMMC7721 cells were directly exposed to the medicated fiber mats, followed with MTT assay. For in vivo evaluation, the medicated mats were locally implanted into H22 tumor-bearing mice, followed with detection of Fas protein and flow cytometry analysis. The results showed that in vitro cytotoxicity of medicated fibers were sustained throughout the whole experiment process with the degradation of fiber matrix, while that of pure Dox was reduced in six days; medicated fibers had superior in vivo anticancer activities to pure Dox (P < 0.01). In conclusion, Doxorubicin-loaded PEG-PLA electrospun fiber mats had the properties of loading doxorubicin hydrochloride (Dox) and sustained release of Dox from medicated fiber matrix and apparently retained both in vitro cytotoxicity and in vivo anticancer activities in a long term. Medicated fiber mats are therefore suitable for a local therapy device. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011Journal of Applied Polymer Science 01/2012; 123(1). · 1.40 Impact Factor
- Journal of controlled release : official journal of the Controlled Release Society. 09/2014; 190:52-3.