Common Variation in the Fat Mass and Obesity-Associated (FTO) Gene Confers Risk of Obesity and Modulates BMI in the Chinese Population

Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan.
Diabetes (Impact Factor: 8.47). 06/2008; 57(8):2245-52. DOI: 10.2337/db08-0377
Source: PubMed

ABSTRACT Genetic variants in the fat mass and obesity-associated (FTO) gene have been linked with obesity and type 2 diabetes in European populations. We aimed to test the role of FTO genetic variants in obesity and type 2 diabetes in the Chinese population.
We genotyped 19 single-nucleotide polymorphisms (SNPs) spanning from the 3' end of the neighboring RPGRIP1L gene to the 5' flanking region of the FTO gene. We analyzed their associations with obesity (638 case and 1,610 control subjects), type 2 diabetes (759 case and 784 control subjects), and obesity-related traits in nondiabetic subjects.
Among the 19 SNPs, the rs9939609 A allele was strongly associated with obesity (P = 7.0 x 10(-4)) and BMI (P = 0.0024) in the Chinese population. The odds ratio for obesity was 2.60 (95% CI 1.24-5.46) (P = 0.011) for the AA genotype and 1.32 (1.05-1.66) (P = 0.018) for the AT genotype compared with the TT genotype. Each additional copy of the rs9936609 A allele was associated with a BMI increase of approximately 0.37 kg/m(2). The rs9939609 A allele was substantially less common in the Chinese population than in the European population (12.6 vs. 45%). We did not find significant associations of the 19 SNPs with type 2 diabetes or other obesity-related traits.
Genetic variation in the FTO gene is strongly associated with obesity and BMI in the Chinese population. The risk variant is less common in the Chinese population, but its effect size on BMI is comparable with that in the European population.

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Available from: Pi-Hua Liu, Jul 30, 2015
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    • "In recent years, of the many genes studied for obesity, the FTO (fat mass-and obesity-associated ) gene has been proven consistently to be associated with increased body mass index (BMI). Since its discovery in 2007 in genomewide association studies for type 2 diabetes [1], several other studies have confirmed the association in different populations [2] [3] [4]. Of the many found associated, the FTO rs9939609 single nucleotide polymorphism (SNP), located in the first intron, is of particular interest since it was the first to be found to be associated with obesity and has been constantly replicated through independent studies of large Caucasian populations [2] [3]. "
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    ABSTRACT: Obesity is recognized as a major health problem worldwide. Genetic factors play a major role in obesity, and genomewide association studies have provided evidence that several common variants within the fat mass- and obesity-associated (FTO) gene are significantly associated with obesity. Very limited data is available on FTO in the Italian population. Aims of our study are to investigate: (1) the association of FTO gene SNPs rs9939609 and rs9930506 with body mass index (BMI) and obesity-related parameters in a large cohort (n = 752) of Italian obese subjects; (2) the association between the two FTO SNPs and age of onset of obesity. Our results demonstrate a strong association between FTO SNPs rs9939609 (P < 0.043) and rs9930506 (P < 0.029) with BMI in the Italian population. FTO rs9930506 was significantly associated with higher BMI in a G allele dose-dependent manner (BMI + 1.4 kg/m2 per G allele). We also observed that the association with BMI of the two FTO variants varied with age, with the carriers of the risk alleles developing an increase in body weight earlier in life. In conclusion, our study further demonstrates a role of the genetic variability in FTO on BMI in a large Italian population.
    Experimental Diabetes Research 02/2012; 2012:872176. DOI:10.1155/2012/872176 · 3.54 Impact Factor
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    • "Common variations in the first intron of the fat mass and obesity associated (FTO) gene, have been shown to be risk factors for obesity in several studies of Caucasian [1] [2] [3], Asian [4] [5] [6] [7] [8] [9] and African American [10] subjects. However, conflicting results have been generated in certain Asian (e.g., Japanese and Chinese) [11] [12] and African American [3] populations. "
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