Eukaryotic-microbiota crosstalk: potential mechanisms for health benefits of prebiotics and probiotics.
ABSTRACT The ability to link dietary consumption of prebiotic food ingredients and probiotic microorganisms to health benefits rests, in part, on our ability to identify both the extent to which these factors alter human microbiome activity and/or structure and the ability to engage eukaryotic cells necessary to transduce signals originating from the microbiome. The human microbiome consists of bacterial, archaeal, and fungal components that reside in mucosal surfaces of the gut, the airways, and the urogenital tract. Characterization of the symbiotic nature of the relationship between eukaryotic cells and the bacterial and archaeal components of the microbiota has revealed significant contributions in energy balance, bowel function, immunologic function, sensory perception, glycemic control, and blood pressure regulation. Elucidating the complex interactions between the microbiota and their associated epithelial, immune, and neural cells may provide mechanistic insights and a rational basis for our belief that dietary consumption of probiotic microorganisms and prebiotics produces health benefits.
SourceAvailable from: Leonard Bielory
Dataset: Fiocchi-2012-Clinical Use of Prob
[Show abstract] [Hide abstract]
ABSTRACT: Nutraceuticals are medicinal foods that enhance health, modulate immunity and thereby prevent and cure specific diseases. They may range from natural diets, herbal products to genetically engineered foods and processed products such as cereals, soups and beverages. Biofortified crops have been considered as a complementary strategy for delivering nutrition to malnourished populations. Dairy products that contain probiotic organisms such as Lactobacillus and Bifidobacterium species represent a new research area which improves gut health by modulating gut microbial composition. The ability of nutraceuticals to influence chronic diseases like diabetes, different types of cancers, etc. should be recognized as an enormous opportunity in their treatment. They will play important role in future therapeutic developments. In this review, an attempt has been made to discuss history, classification, commercial products and regulations of nutraceuticals.International Journal of Pharmacy and Biological Sciences 01/2012; 2(1):177-187.
[Show abstract] [Hide abstract]
ABSTRACT: The mechanism by which probiotic lactobacilli affect the immune system is strain specific. As the immune system is multi-compartmental system, each strain has his way to interact with it and induce a visible and quantifiable effect. This review summarises the interplay existing between the host immune system, with emphasis on lactobacilli as a prototype probiotic genus. Several aspects including the bacterial-host cross-talk with the mucosal and systemic immune system are presented, as well as short sections on the competing effect toward pathogenic bacteria and their uses as delivery vehicle for antigens.This article is protected by copyright. All rights reserved.Journal of Applied Microbiology 08/2014; 117(2):303-319. DOI:10.1111/jam.12521 · 2.39 Impact Factor