Article

Covalent inhibitors of glycosidases and their applications in biochemistry and biology

Department of Chemistry, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
Glycobiology (Impact Factor: 3.14). 09/2008; 18(8):570-86. DOI: 10.1093/glycob/cwn041
Source: PubMed

ABSTRACT Glycoside hydrolases are important enzymes in a number of essential biological processes. Irreversible inhibitors of this class of enzyme have attracted interest as probes of both structure and function. In this review we discuss some of the compounds used to covalently modify glycosidases, their use in residue identification, structural and mechanistic investigations, and finally their applications, both in vitro and in vivo, to complex biological systems. © The Author 2008. Published by Oxford University Press. All rights reserved.

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Nov 6, 2014