Article

Normal differential renal function does not indicate a normal kidney after partial ureteropelvic obstruction and subsequent relief in 2-week-old piglets.

Institute of Clinical Medicine, University of Aarhus, Aarhus, Denmark.
European journal of nuclear medicine and molecular imaging (Impact Factor: 5.11). 06/2008; 35(9):1673-80. DOI: 10.1007/s00259-008-0822-1
Source: PubMed

ABSTRACT We investigated the functional consequences of relieving ureteric obstruction in young pigs with experimental hydronephrosis (HN) induced by partial unilateral ureteropelvic obstruction.
Three groups of animals were followed from the age of 2 weeks to the age of 14 weeks: Eight animals had severe or grades 3-4 HN throughout the study. Six animals had relief of the obstruction after 4 weeks. Six animals received sham operations at both ages. Morphological and functional examinations were performed at age 6 weeks and again at age 14 weeks and consisted of magnetic resonance imaging (MRI), technetium-diethylenetriaminepentaaceticacid ((99m)Tc-DTPA) renography, renal technetium-dimercaptosuccinicacid ((99m)Tc-DMSA) scintigraphy, and glomerular filtration rate (GFR) measurement.
After relief of the partial obstruction, there was reduction of the pelvic diameter and improvement of urinary drainage. Global and relative kidney function was not significantly affected by either obstruction or its relief. Renal (99m)Tc-DMSA scintigraphy showed a change in both the appearance of the kidney and a change in the distribution within kidneys even after relief of obstruction.
This study shows that partial ureteric obstruction in young pigs may be associated with little effect on global and differential kidney function. However, even after relief of HN, the distribution of (99m)Tc-DMSA in the kidney remains abnormal suggesting that a normal differential renal function may not represent a normal kidney.

0 Bookmarks
 · 
165 Views
  • [Show abstract] [Hide abstract]
    ABSTRACT: Large scale Australian civilian medical assistance teams were first deployed overseas in 2004. The deployment of small Forward Teams in the early phase of a health disaster response allows for informed decisions on whether, and in what form, to deploy larger medical assistance teams. The prime consideration is to support the capacity of local services to respond to the specific needs of the affected population. In addition, Australian citizens caught up in large numbers in overseas disasters may need health assistance.
    Travel Medicine and Infectious Disease 07/2011; 9(5):249-52. · 1.78 Impact Factor