The validity of self-reported prescription medication use among adolescents varied by therapeutic class

Norwegian Institute of Public Health, Division of Epidemiology, P.O. Box 4404 Nydalen, N-0403 Oslo, Norway.
Journal of Clinical Epidemiology (Impact Factor: 5.48). 08/2008; 61(7):714-7. DOI: 10.1016/j.jclinepi.2007.11.013
Source: PubMed

ABSTRACT Validation studies of self-reported medication use in adolescents have been scarce. The objective of this study was to estimate the sensitivity and specificity of self-reported use of medication using a prescription database as reference standard.
The study population consisted of a cohort of 2,613 adolescents aged 15-16 years from the Norwegian youth health survey in 2004 and 2005. Self-reported data on medication use were compared with data from the Norwegian Prescription Database which contains information from all prescription dispensed at Norwegian pharmacies.
Sensitivity for self-reported questions on medication use was highest for contraceptive pills 99.2% (95% CI 97.7-100) compared to antiasthmatics 79.1% (66.9-91.2), painkillers 48.5% (36.7-60.4), and psychotropic drugs 75.0% (35.6-95.6). Specificity values of self-reported information of psychotropic drugs 89.6% (87.8-91.5) and antiasthmatics 87.4% (85.4-89.5) were higher than for painkillers 80.0% (77.5-82.4) and contraceptive pills 76.2% (72.3-80.1).
Validity of self-reported previous medication use among adolescents differed by the therapeutic classes of medication. The highest sensitivity was observed for contraceptive pills and lowest for prescribed painkillers.

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