Benign neonatal sleep myoclonus.

Epilepsy Treatment and Research Unit, Federal University of São Paulo.
Epileptic disorders: international epilepsy journal with videotape (Impact Factor: 1.17). 07/2008; 10(2):177-80. DOI: 10.1684/epd.2008.0196
Source: PubMed

ABSTRACT Benign neonatal sleep myoclonus is a non-epileptic disorder. This phenomenon of the first weeks of life is characterized by erratic myoclonic jerks occurring only during sleep and with no electroencephalographic changes. It is not associated with perinatal complications, disappears spontaneously within two to four months, and it does not compromise future development. We illustrate with a video this relatively frequent condition, which is often misdiagnosed as epileptic in nature, and discuss the clinical characteristics and differential diagnosis.

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    ABSTRACT: Benign neonatal sleep myoclonus is a non-epileptic movement disorder that may mimic neonatal seizures. The aim of this study was to clarify the clinical manifestations and outcomes in Japanese infants with benign neonatal sleep myoclonus. We reviewed the clinical manifestations and outcomes in 15 consecutive patients with benign neonatal sleep myoclonus (males: 10), including three paired familial cases, referred to our center between 1996 and 2011. The diagnosis of benign neonatal sleep myoclonus was based on a neonatal onset, characteristic myoclonic jerks that occurred during sleep, and normal electroencephalogram findings. All were healthy full-term neonates at birth. The age at onset ranged from 1 to 18days (median: 7days). Prior to referral to our center (3-8weeks), two infants had been placed on antiepileptic drugs, without effects. During the clinical course, the myoclonic jerks resolved by 6months in 14 of the 15 patients. On follow-up (final evaluation, mean: 38months), all but one patient (speech delay) showed normal development. None developed epilepsy. Of note, migraine occurred after 5years of age in three children, including one who developed cyclic vomiting syndrome, evolving to migraine. Another boy developed cyclic vomiting syndrome, a precursor of migraine, before 1year, and was being followed. A high incidence of migraine was observed in five (42%) of 12 parents whose detailed family history was available. Our study suggests that benign neonatal sleep myoclonus is related to migraine. With the high rate of familial cases, further genetic study, including migraine-related gene analysis, is necessary to determine the underlying mechanism responsible for benign neonatal sleep myoclonus.
    Brain & development 04/2014; · 1.74 Impact Factor

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