[Pathomechanism of autoantibody production in neurological disorders].

Abstract

In immune-mediated neurological disorders, various autoantibodies against neuronal tissues have been discovered. Although some of these antibodies have been found to correlate with the pathomechanism of the disease, most remain disease markers with unknown pathomechanisms. In paraneoplastic neurological disorders, tumor tissues express neuronal-like proteins that activate the host immune system and produce autoantibodies against the host' s own neuronal tissues. In axonal Guillain-Barré syndrome, antiganglioside antibodies are produced by the mechanism of molecular mimicry between gangliosides in the axon and lipooligosaccharides of the antecedent infectious pathogen. In addition, the disruption of the host immune system plays an important role for developing the disease.