Delusions and Hallucinations in Frontotemporal Dementia

Department of Clinical Neurological Sciences, Division of Neurology, St Joseph's Hospital, University of Western Ontario, Ontario, Canada.
Cognitive and behavioral neurology: official journal of the Society for Behavioral and Cognitive Neurology (Impact Factor: 0.95). 07/2008; 21(2):107-10. DOI: 10.1097/WNN.0b013e3181799e19
Source: PubMed


Frontotemporal dementia (FTD) is associated with marked behavior changes, but hallucinations and delusions are rare.
To report a case of FTD with early and persistent delusions, including de Clerambault syndrome.
We describe the clinical, neuroradiologic, and neuropathologic findings of a 76-year-old woman with an 11-year course of FTD with bizarre delusions and hallucinations.
The patient's autopsy examination of the brain revealed pathology consistent with frontotemporal lobar degeneration with ubiquitin-positive and transactive response (TAR)-DNA-binding protein-43-positive inclusions and hippocampal sclerosis.
Delusions and hallucinations can occur in proven frontotemporal pathology.

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Available from: Maria Carmela Tartaglia,
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    • "When considering the occurrence of delusions, strict associations were found with GM volumes in the hip- pocampus. This region has already been reported as implicated in the generation of delusions in patients with schizophrenia [79] [80] [81], fronto-temporal dementia [82], and temporal lobe epilepsy [83]. Misidentification of person, places, or objects, in association with delusional memories and content-related confabulations were the types of delusions detected, by NPI-12, in our study. "
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