Article

[C1772T polymorphism of hypoxia-inducible factor-1 alpha gene in Han ethnic population from Northern China].

Department of Sports and Human Science, Wenzhou Medical College, Wenzhou 325035, China.
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 06/2008; 37(3):267-70. pp.267-70
Source: PubMed

ABSTRACT To analyze the distribution of single nucleotide polymorphism C1772T (SNP/C1772T) in hypoxia-inducible factor -1 alpha (HIF-1 alpha) gene in Han ethnic population from Northern China.
Allele frequencies in a sample of 206 healthy Chinese Hans were determined by polymerase chain reaction followed by restriction fragment length polymorphism.
The genotype frequencies of C1772T observed in Chinese Hans were 93 % and 7% for CC and CT respectively; and allele frequencies were 96% and 4 %for C and T respectively. There was significant difference in distribution of allele frequencies between Chinese Hans and Caucasian.
The single nucleotide polymorphism of C1772T in HIF-1 alpha gene has difference in different ethnic population.

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Keywords

206 healthy Chinese Hans
 
allele frequencies
 
Chinese Hans
 
CT
 
different ethnic population
 
genotype frequencies
 
Han ethnic population
 
HIF-1 alpha
 
HIF-1 alpha gene
 
hypoxia-inducible factor -1 alpha
 
Northern China
 
polymerase chain reaction
 
restriction fragment length polymorphism
 
single nucleotide polymorphism
 
single nucleotide polymorphism C1772T