Article

Unrecognised severe vitamin D deficiency

Endocrine Unit, Royal Victoria Infirmary, Newcastle Upon Tyne NE1 4LP.
BMJ (online) (Impact Factor: 16.38). 07/2008; 336(7657):1371-4. DOI: 10.1136/bmj.39555.820394.BE
Source: PubMed

ABSTRACT Vitamin D deficiency remains common and may mimic other musculoskeletal disorders or mental health problems

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Available from: Richard Quinton, Aug 31, 2015
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    • "In addition, it has been more recently suggested that vitamin D deficiency is associated with Graves' disease [14] [15] [16]. However, vitamin D deficiency as a cause of hypocalcemia has received little attention [17] [18]. In this report, we present the case of a 41-year-old Japanese female office worker who developed symptomatic hypocalcemia with severe vitamin D deficiency following treatment for Graves' disease with MMI. "
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    ABSTRACT: We herein report the case of a 41-year-old Japanese female office worker who developed symptomatic hypocalcemia with severe vitamin D deficiency following treatment for Graves' disease with methimazole. The patient's hypocalcemia was mainly caused by vitamin D deficiency due to unbalanced diets and inadequate exposure to sunlight in addition to the resolution of hyperthyroidism. Vitamin D deficiency is increasing worldwide, and it has been more recently shown to relate to the pathogenesis of Graves' disease. However, vitamin D deficiency as a cause of hypocalcemia has received little attention. Taken together, this case suggests that we should take more care in calcium kinetics and vitamin D status during treatment for Graves' disease with antithyroid drugs.
    04/2013; 2013:512671. DOI:10.1155/2013/512671
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    • "Treatment of established deficiency requires higher doses of vitamin D. One strategy for treating deficiency due to dietary or sunlight deficiency is to give 50,000 IU of ergocalciferol orally once weekly for 8 weeks, repeating for another 8 weeks if vitamin D levels remain < 75 nM [1]. Another simple regimen is to give ergocalciferol 10,000 IU orally once daily during this treatment period [24], or intramuscular colecalciferol 300,000 IU monthly [24]. Vitamin D deficiency secondary to more complex causes or when renal failure is present may need still higher doses or, if vitamin D metabolism is significantly impaired, calcitriol (1,25-hydroxycolecalciferol) [25]. "
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    BMC Research Notes 02/2009; 2:82. DOI:10.1186/1756-0500-2-82
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