Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1. N Engl J Med

Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
New England Journal of Medicine (Impact Factor: 54.42). 07/2008; 358(25):2698-703. DOI: 10.1056/NEJMoa0800251
Source: PubMed

ABSTRACT We developed an in vitro method for isolating and expanding autologous CD4+ T-cell clones with specificity for the melanoma-associated antigen NY-ESO-1. We infused these cells into a patient with refractory metastatic melanoma who had not undergone any previous conditioning or cytokine treatment. We show that the transferred CD4+ T cells mediated a durable clinical remission and led to endogenous responses against melanoma antigens other than NY-ESO-1.

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Available from: Cassian Yee, Aug 22, 2015
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    • "umor responses following administration of various immunotherapeutic strategies in the absence of cytoablative treat - ments , and have suggested that such responses are likely due to the balance between effector T cells ( i . e . , either CD4 or CD8 ) and TReg cells within treated cancer patients ( Alvaro et al . , 2005 ; Quezada et al . , 2006 ; Hunder et al . , 2008 ; Le and Jaffee , 2012 ; Liu et al . , 2012a ) . Along these lines , in our clinical study investigating adop - tive T cell therapy using autologous Th1 - like effector cells in the treatment of ovarian cancer patients , we observed enhanced T cell - mediated immune responses in long - term surviving patients that appeared to correlate "
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    Frontiers in Oncology 03/2013; 3:63. DOI:10.3389/fonc.2013.00063
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    • "Aberrant CTA expression was first described in melanoma; as such, this expression was found to generate CTA-specific cytotoxic T-cell responses [47]. Recently, it was reported that treatment of metastatic melanoma with autologous CD4 + T cells specific for the CTA, NY-ESO- 1, elicited long-term complete remission [48]. In addition to melanoma, CTA expression has also been observed in hematological malignancies [49] as well as solid tumors, including breast cancer [50] [51]. "
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    • "CTA offer such a target, and have been subject of intense study because of their aberrant expression in a variety of tumours. In patients with malignant melanoma, CTAG1B reactive T cells have been isolated and expanded ex vivo and re-infused into autologous recipients with dramatic responses recorded (Hunder et al, 2008). Recently, in vitro evidence of CTA overexpression by epigenetic modification and an adaptive T cell response has been demonstrated against MAGEA4 in patients with Hodgkin lymphoma treated with decitabine (Cruz et al, 2011). "
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