The role of colonic metabolism in lactose intolerance

TI Food and Nutrition, Wageningen, The Netherlands.
European Journal of Clinical Investigation (Impact Factor: 2.83). 07/2008; 38(8):541-7. DOI: 10.1111/j.1365-2362.2008.01966.x
Source: PubMed

ABSTRACT Lactose maldigestion and intolerance affect a large part of the world population. The underlying factors of lactose intolerance are not fully understood. In this review, the role of colonic metabolism is discussed, i.e. fermentation of lactose by the colonic microbiota, colonic processing of the fermentation metabolites and how these processes would play a role in the pathophysiology of lactose intolerance. We suggest that the balance between the removal and production rate of osmotic-active components (lactose, and intermediate metabolites, e.g. lactate, succinate, etc.) in the colon is a key factor in the development of symptoms. The involvement of the colon may provide the basis for designing new targeted strategies for dietary and clinical management of lactose intolerance.

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Available from: Roel Vonk, Feb 24, 2014
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    • "Lactose is hydrolyzed by lactase in intestines. Lactose intolerance is when a person has difficulty or is unable to digest milk due to lack of lactase (Harrington et al., 2008, Venema, 2008). Children with suspected lactose intolerance can be assessed clinically by dietary lactose elimination or by tests including noninvasive hydrogen breath testing or invasive intestinal biopsy determination of lactase (and other disaccharidase) concentrations. "
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