Tooth agenesis: from molecular genetics to molecular dentistry.

Institute of Animal Physiology and Genetics, Academy of Sciences, Brno, Czech Republic.
Journal of Dental Research (Impact Factor: 4.14). 08/2008; 87(7):617-23. DOI: 10.1177/154405910808700715
Source: PubMed

ABSTRACT Tooth agenesis may originate from either genetic or environmental factors. Genetically determined hypodontic disorders appear as isolated features or as part of a syndrome. Msx1, Pax9, and Axin2 are involved in non-syndromic hypodontia, while genes such as Shh, Pitx2, Irf6, and p63 are considered to participate in syndromic genetic disorders, which include tooth agenesis. In dentistry, artificial tooth implants represent a common solution to tooth loss problems; however, molecular dentistry offers promising solutions for the future. In this paper, the genetic and molecular bases of non-syndromic and syndromic hypodontia are reviewed, and the advantages and disadvantages of tissue engineering in the clinical treatment of tooth agenesis are discussed.

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