Tooth Agenesis: from Molecular Genetics to Molecular Dentistry

Institute of Animal Physiology and Genetics, Academy of Sciences, Brno, Czech Republic.
Journal of Dental Research (Impact Factor: 4.14). 08/2008; 87(7):617-23. DOI: 10.1177/154405910808700715
Source: PubMed


Tooth agenesis may originate from either genetic or environmental factors. Genetically determined hypodontic disorders appear as isolated features or as part of a syndrome. Msx1, Pax9, and Axin2 are involved in non-syndromic hypodontia, while genes such as Shh, Pitx2, Irf6, and p63 are considered to participate in syndromic genetic disorders, which include tooth agenesis. In dentistry, artificial tooth implants represent a common solution to tooth loss problems; however, molecular dentistry offers promising solutions for the future. In this paper, the genetic and molecular bases of non-syndromic and syndromic hypodontia are reviewed, and the advantages and disadvantages of tissue engineering in the clinical treatment of tooth agenesis are discussed.

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    • "Oral cancers and their treatments often affect the structure and physiological function of more than one orofacial tissues and organs. In particular, radiotherapy and chemotherapy strongly affect salivary gland function, resulting in severe swallowing problems, dental caries and tooth loss (Cooper et al., 1995; Langendijk et al., 2008; Marec-Berard et al., 2005; Matalova et al., 2008; Minicucci et al., 2003). All these conditions mentioned above affect tooth functionality. "
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    ABSTRACT: Stem cell-based mediated therapies represent very promising approaches for tissue regeneration and are already applied with success in clinics. These therapeutic approaches consist of the in vitro manipulation of stem cells and their consequent administration to patients as living and dynamic biological agents. Nevertheless, the deregulation of stem cells function might result in the generation of pathologies such as tumours or accelerated senescence. Moreover, different stem cells sources are needed for regeneration of specific tissues. It is thus fundamental to understand the mechanisms regulating the physiology of stem cells. Microfluidic technology can be used to mimic in vivo scenarios and allow the study of stem cell physiology at both single cell and whole stem cell niche levels.This review focuses on the potential sources of stem and progenitor cells for orofacial regeneration and the use of microfluidic technologies for the study of stem cells behaviour and stem cell niches, in the light of regenerative medicine.
    European cells & materials 03/2015; 29:213-223. · 4.89 Impact Factor
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    • "The aetiological factors associated with hypodontia include physical disruption of the lamina dura, abnormalities of the dental epithelium, and underlying neural crest derived mesenchyme failing to induce tooth germ production [20]. There is a strong genetic basis with MSX1, TGFA, and PAX9 mutations isolated for tooth agenesis [21]. More recently, WNT10A has been isolated and shown to improve the diagnostic yield of DNA testing in isolated nonsyndromic hypodontia [22]. "
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    ABSTRACT: Although hypodontia and supernumerary teeth are often considered as mutually exclusive conditions, this case report presents an unusual case of hypodontia and a supernumerary tooth occurring simultaneously. An adolescent male was referred to the local hospital department regarding upper arch crowding. Plain film radiographs confirmed the congenital absence of both lower lateral incisors in addition to an unerupted conical supernumerary tooth in the maxillary midline. This condition has been called hypo-hyperdontia and in this paper, we discuss the clinical findings and treatment planning considerations in relation to the limited number of previously reported cases. The case report raises awareness of concomitant hypo-hyperdontia and serves to highlight that concomitant anomalies should be excluded when hypodontia or supernumerary teeth are diagnosed.
    09/2013; 2013(7):598727. DOI:10.1155/2013/598727
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    • "Many researchers have suggested a multifactorial etiology of oligodontia, combining multigenic and environmental influences.[101112] Developing teeth are influenced by endocrine, local and environmental factors such as radiotherapy, chemotherapy, jaw fractures, surgical procedures on the jaws, or the extraction of the preceding deciduous teeth.[1314] "
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    ABSTRACT: This case report defines a case of isolated oligodontia of 9 and 10 permanent teeth in 9-year-old monozygotic twin sisters and gives information about the possible genetic and environmental etiology, related dental anomalies and treatment options. The twins have a negative family history of hypodontia and oligodontia in their parents, as well as their paternal and maternal grandmothers and first cousins. No other dental anomalies could be detected in either of the twins. With the occurrence of similarly located tooth agenesis, except for one tooth, in monozygotic twins, one may consider the influence of genetic and/or environmental factors in their etiology. Hereditary relationships associated with oligodontia could help the clinicians to predict the possibility of its occurrence in other family members and in the next generations. However, clinicians should consider oligodontia when it is not hereditary.
    European journal of dentistry 09/2013; 7(Suppl 1):S111-4. DOI:10.4103/1305-7456.119087
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