Tumor-Inhibitory Effect and Immunomodulatory Activity of Fullerol C 60 (OH) x
ABSTRACT The tumor-inhibitory effect of C60(OH)x was tested on the murine H22 hepatocarcinoma model. Doses of 0.2 and 1.0 mg kg(-1) body weight both showed significant antitumor activity with tumor inhibition rates of 31.9 and 38.4%, respectively, when mice were treated for 17 consecutive days. The damnification of liver was prominently reduced. Furthermore, histological examination indicated that an envelope of fibroblasts and lymphocytes was formed surrounding tumor tissues in the C60(OH)x-treated group, which inhibited the infiltration of tumor to the neighboring normal skeleton muscle tissues. To understand the antitumor mechanism, the immunomodulatory activity of C60(OH)x was investigated. The results indicate that C60(OH)x enhances the phagocytosis of peritoneal macrophages and elevates the activity of arginase and acid phosphatase in vivo. The tumor necrosis factor alpha production of C60(OH)x-treated macrophages also increases in vitro. These results suggest that C60(OH)x can enhance the innate immunity of tumor-bearing mice, and therefore inhibits growth of the tumor.
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- "Since 1993 countless studies showed that fullerene (C 60 ) and derivatives exhibit paramount potentialities in several fields of biology and medicine  mainly including specific DNA cleavage, imaging , UV and radioprotection , antiviral, antioxidant, and anti-amyloid activities [1,4e7], allergic response  and angiogenesis  inhibitions, immune stimulating and antitumour effects  , enhancing effect on neurite outgrowth , gene delivery , and even hair-growing activity . However, although several independent research groups confirmed the innocuousness of pristine C 60 [15e17] the toxicity of this fullerene is still a matter of debate  . "
ABSTRACT: Countless studies showed that fullerene (C(60)) and derivatives could have many potential biomedical applications. However, while several independent research groups showed that C(60) has no acute or sub-acute toxicity in various experimental models, more than 25 years after its discovery the in vivo fate and the chronic effects of this fullerene remain unknown. If the potential of C(60) and derivatives in the biomedical field have to be fulfilled these issues must be addressed. Here we show that oral administration of C(60) dissolved in olive oil (0.8 mg/ml) at reiterated doses (1.7 mg/kg of body weight) to rats not only does not entail chronic toxicity but it almost doubles their lifespan. The effects of C(60)-olive oil solutions in an experimental model of CCl(4) intoxication in rat strongly suggest that the effect on lifespan is mainly due to the attenuation of age-associated increases in oxidative stress. Pharmacokinetic studies show that dissolved C(60) is absorbed by the gastro-intestinal tract and eliminated in a few tens of hours. These results of importance in the fields of medicine and toxicology should open the way for the many possible -and waited for- biomedical applications of C(60) including cancer therapy, neurodegenerative disorders, and ageing.Biomaterials 04/2012; 33(19):4936-46. DOI:10.1016/j.biomaterials.2012.03.036 · 8.31 Impact Factor
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ABSTRACT: This paper describes the series capacitors installed in the 500 kV 580 mile long Peace River transmission system in British Columbia, Canada. The installations feature one of the world's biggest banks (1012 MVAR installed capacity), internally fused capacitors, and electronic control system. The aspects discussed are general design features, portection and control functions, commissioning tests and staged fault tests. Recent operating experience with these stations is also submitted. The information given here would be valuable for utility planners considering series compensation.IEEE Transactions on Power Apparatus and Systems 12/1977; DOI:10.1109/T-PAS.1977.32508
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ABSTRACT: The effects of fullerenol C60(OH)24 (Frl) at doses of 25, 50, and 100mg/kg/week (for a time-span of 3 weeks) on heart and liver tissue after doxorubicin (Dox)-induced toxicity in rats with colorectal cancer were investigated. In the present study, we used an in vivo Wistar male rat model to explore whether Frl could protect against Dox-induced (1.5mg/kg/week for 3 weeks) chronic cardio- and hepato- toxicity and compared the effect with a well-known antioxidant, vitamin C (100mg/kg/week for 3 weeks). According to macroscopic, microscopic, hematological, biochemical, physiological, pharmacological, and pharmacokinetic results, we confirmed that, at all examined doses, Frl exhibits a protective influence on the heart and liver tissue against chronic toxicity induced by Dox.Biomaterials 12/2008; 30(6):1184-96. DOI:10.1016/j.biomaterials.2008.10.060 · 8.31 Impact Factor