Cancer treatment and the ovary - The effects of chemotherapy and radiation

Division of Endocrinology, 300 Longwood Avenue, Boston, MA 02115, USA.
Annals of the New York Academy of Sciences (Impact Factor: 4.31). 07/2008; 1135:123-5. DOI: 10.1196/annals.1429.023
Source: PubMed

ABSTRACT Certain chemotherapeutic drugs ("alkylators") and radiation therapy are toxic to the ovaries, leading to both loss of sex steroid hormone production and infertility. Higher doses and older age at treatment are both associated with greater damage. Even patients with spontaneous menstrual cycles have evidence of decreased ovarian potential. Adolescents who are treated for cancer with these agents should be counseled about future fertility risks.

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    • "Disease, senescence and radio-and chemotherapy for cancer treatment can result in the complete loss of female reproductive capacity and premature ovarian failure, especially when alkylating drugs and pelvic radiation are involved (Larsen et al., 2003; Wallace and Thomson, 2003; Agarwal and Chang, 2007; Cohen, 2008; Oktem and Oktay, 2009). In order to preserve fertility, there is a demand to improve cryopreservation and follicle culture, and assess safety of cryopreservation for oocyte health and genomic integrity (Gook and Edgar, 2007; Amorim et al., 2009; Smitz et al., 2010). "
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