Article

Surgical and endovascular treatments for intracranial aneurysms.

Department of Neurological Surgery and Radiology, The Feinberg School of Medicine, Northwestern University, 676 North St. Clair Street, Suite 2210, Chicago, IL 60611, USA.
Current Treatment Options in Cardiovascular Medicine 07/2008; 10(3):241-52. pp.241-52
Source: PubMed

ABSTRACT The goals of microsurgical and endovascular treatment of intracranial aneurysms are to prevent subarachnoid hemorrhage and/or eliminate mass effect symptoms. Debate has raged regarding which aneurysms to treat and with which technique or combination of techniques. It is our impression that studies that have assessed aneurysm natural history and treatment options are compromised by the inherent limitations of clinical trials, with many natural history studies likely underestimating rupture risk over long-term follow-up. Endovascular therapy and open neurosurgery should both be used strategically, and our current interest is in integrating these techniques in a fashion extending beyond the simplistic clip-versus-coil debate.

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Keywords

aneurysm natural history
 
clinical trials
 
current interest
 
endovascular treatment
 
intracranial aneurysms
 
long-term follow-up
 
mass effect symptoms
 
natural history studies likely underestimating rupture risk
 
simplistic clip-versus-coil debate
 
strategically
 
subarachnoid hemorrhage
 
treatment options