How depression may increase cardiac risk: effect of hypercortisolism on platelet activation markers: preliminary data.
ABSTRACT Hypercortisolism, as seen in the majority of patients with major depression, may be associated with the generation of platelets that show signs of increased activation.
Within a study using a placebo-controlled double-blind cross-over design, 9 healthy subjects ingested hydrocortisone (daily dose = 40 mg) or placebo on 7 consecutive days. At the end of each study segment, we analyzed platelets for the surface activation markers P-selectin, glycoprotein 53, and PAC-1 and measured platelet-leucocyte aggregates in serum.
Hydrocortisone ingestion was not associated with changes in the platelet activation markers P-selectin and PAC-1 or the number of circulating platelet-leucocyte aggregates but with a trend (p = 0.056) toward higher expression of glycoprotein 53 on the platelet surface.
Induction of hypercortisolism in healthy volunteers was not associated with a major increase in platelet activation markers.
Article: The influence of pituitary, adrenal, and parathyroid hormones on hemostasis and thrombosis.[show abstract] [hide abstract]
ABSTRACT: Endocrine disorders can influence the hemostatic balance. Abnormal coagulation test results have been observed in patients with abnormal hormone levels. The present review updates the available evidence on the influence of pituitary, adrenal, and parathyroid hormones on the coagulation and the fibrinolytic system, and their possible clinical implications. The literature supports a possible relevant clinical effect of the imbalance between coagulation and fibrinolysis on thrombotic events in endogenous Cushing's syndrome. An effect on markers of coagulation and fibrinolysis has been shown for hyperprolactinemia, growth hormone excess or deficiency, exogenous hypercortisolism, pheochromocytoma, primary hyperaldosteronism, and hyperparathyroidism. However, the clinical relevance is still unproven. Until definitive evidence is available, clinicians should be aware of the possibility that endocrine disorders may be risk factors for thrombotic events.Seminars in Thrombosis and Hemostasis 02/2011; 37(1):41-8. · 4.52 Impact Factor