The impact of cataract surgery on cognitive impairment and depressive mental status in elderly patients
ABSTRACT To evaluate the influence of cataract surgery on cognitive function and depressive mental status of elderly patients.
Prospective, interventional case series.
The 25-Item National Eye Institute Visual Functioning Questionnaire (NEI VFQ-25), Mini-Mental State Examination (MMSE), and Beck Depression Inventory (BDI) are the measures designed to assess vision-related quality of life (QOL), cognitive impairment, and depressive mental status, respectively. These tests were performed before and two months after surgery in 102 patients undergoing phacoemulsification and intraocular lens implantation for bilateral cataract.
The change in best-corrected visual acuity by surgery significantly correlated with the change in NEI VFQ-25 score (Pearson correlation, r = -0.310; P = .031). The change in NEI VFQ-25 score by surgery significantly correlated with the change in MMSE score (r = 0.306; P = .035) and the change in BDI score (r = -0.414; P < .001). The change in MMSE score showed significant correlation with the change in BDI score (r = -0.434; P < .001).
Vision-related QOL, cognitive impairment, and depressive mental status are all strongly related with each other. Cataract surgery significantly improved vision-related QOL in elderly patients, and cognitive impairment and depressive mental status also improved in parallel with improvement in vision-related QOL.
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ABSTRACT: Purpose. The purpose of this study is to evaluate the vision related quality of life in patients with keratoconus by using the National Eye Institute Visual Function Questionnaire-25 (NEI-VFQ-25). Methods. Thirty patients presented with keratoconus (keratoconus group) and 30 healthy patients (control group) were included in this study. Twenty patients were using rigid gas permeable and 10 patients were not using contact lenses in keratoconus group. High and low contrast visual acuity and mean K values of the patients were recorded. Each subject completed the 25-item NEI-VFQ-25. Results. All subscales of NEI-VFQ-25 were lower in the keratoconus patients. The difference was more evident in the subscales of general vision, ocular pain, near vision, vision-specific mental health, vision-specific role difficulties, and peripheral vision . Overall composite score was 75.2 +/- 17.2 in the keratoconus group and 93.2 +/- 5.6 in the control group . Contact lens wearers had higher best corrected visual acuity in comparison with noncontact lens wearers . Patients with low visual acuity (logMAR > 0.4) in the better eye had lower distance vision, social functioning, mental health, and role difficulties. Meanwhile, patients with low visual acuity (logMAR > 0.4) in the worse eye had lower general health scores . Conclusions. Vision related quality of life was worse in keratoconus patients. Success in the contact lens usage and maintaining higher visual acuity may improve vision related quality of life.Journal of Ophthalmology 04/2014; 2014. DOI:10.1155/2014/694542 · 1.94 Impact Factor
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ABSTRACT: The DBA/2J mouse is a model of pigmentary glaucoma in humans as it shows age-related increases in intraocular pressure (IOP), retinal ganglion cell death and visual impairment. Previously, we showed that visual ability declines from 9 to 12 months of age and visual impairment is correlated with poor learning and memory performance in visuo-spatial tasks but not in tasks that do not depend on visual cues. To test the "sensory impairment" hypothesis of aging, which postulates that sensory impaired individuals are disadvantaged in their performance on psychometric tests as a direct result of difficulties in sensory perception, we treated DBA/2J mice with a conventional glaucoma medication used in humans (Timoptic-XE, 0.00, 0.25, or 0.50%) daily from 9 weeks to 12 months of age to determine whether prevention of vision loss prevented the decline in visuo-spatial learning and memory performance. At all ages tested (3, 6, 9, and 12 months of age), mice treated with Timoptic-XE (0.25 and 0.50%) maintained a high level of performance, while 12 month old control mice (0.00%) exhibited impaired performance in visually-dependent, but not non-visual tasks. These results demonstrate that when sensory function is preserved, cognitive performance is normalized. Thus, as in many aging humans, DBA/2J mice show age-related decrements in performance on visually presented cognitive tests, not because of cognitive impairment but as a direct consequence of poor visual ability. Our results demonstrate that age-related impairment in performance in visuo-spatial tasks in DBA/2J mice can be prevented by the preservation of visual ability.Frontiers in Aging Neuroscience 09/2013; 5:52. DOI:10.3389/fnagi.2013.00052 · 2.84 Impact Factor
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ABSTRACT: The present paper deals with spherically symmetric deformation of an inclusion- matrix problem, which consists of an infinite isotropic matrix and a spherically uniform anisotropic piezoelectric inclusion. The interface between the two phases is supposed to be perfect and the system is subjected to uniform loadings at infinity. Exact solutions are obtained for solid spherical piezoelectric inclusion and isotropic matrix. When the system is subjected to a remote traction, analytical results show that remarkable nature exists in the spherical inclusion. It is demonstrated that an infinite stress appears at the center of the inclusion. Furthermore, a cavitation may occur at the center of the inclusion when the system is subjected to uniform tension, while a black hole may be formed at the center of the inclusion when the applied traction is uniform pressure. The appearance of different remarkable nature depends only on one non-dimensional material parameter and the type of the remote traction, while is independent of the magnitude of the traction.Acta Mechanica Solida Sinica 06/2008; 21(3):278-282. DOI:10.1007/s10338-008-0831-4 · 0.65 Impact Factor