Rush oral immunotherapy in children with persistent cow's milk allergy

Department of Pediatric Pneumology and Immunology, Charité, Campus-Virchow-Klinikum, Berlin, Germany.
The Journal of allergy and clinical immunology (Impact Factor: 11.25). 08/2008; 122(2):418-9. DOI: 10.1016/j.jaci.2008.06.002
Source: PubMed
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    • "La réapparition de signes cliniques au cours de l'augmentation progressive des PLV a ` domicile ne doit pas entraıˆner un retour a ` un régime d'exclusion strict, car il est probable que le maintien de petites doses tolérées de PLV facilite l'acquisition de la tolérance [3] [4]. Plusieurs e ´tudes, utilisant des protocoles courts ou longs ont montré que la désensibilisation représentait une vraie alternative pour les allergies sévères persistantes [10] [11] [12] [13] [14] [15]. Malgré les réserves de Sopo et al. [16] concernant sa sécurité et l'absence de consensus sur sa réalisation, presque la moitié des centres pratique la désensibilisation, mais seulement 36 % des CHU. "
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    ABSTRACT: The outcome of cow milk allergy (CMA) usually progresses to acquisition of tolerance, allowing a normal diet. This study conducted in France aimed to survey practices of milk reintroduction after an exclusion diet. A questionnaire was sent to 278 pediatric centers, exploring the reintroduction procedure in the 3 main types of CMA and in patients with persistent allergy. The response rate was 27%, 53% for tertiary centers and 23% for secondary centers. Cow's milk is reintroduced at a median age of 12 months, and after 6 months of exclusion diet whatever the type of allergy. In about half the centers, Prick-Tests and specific IgE are tested before milk reintroduction, but the procedure in case of a positive test differs between centers. Procedures are similar regarding the type of milk, the quantity, the place (home or hospital), the presence of an intravenous line, and the time before a second reintroduction. A desensitization procedure is proposed in 43% of centers in case of persistent allergy, after 2 reintroduction failures, and at a median age of 2.5 years. Milk reintroduction procedures are similar to those for oral challenge for the diagnosis of CMA but with differences between centers.
    Archives de Pédiatrie 11/2013; 20(11):1206–1211. DOI:10.1016/j.arcped.2013.08.005 · 0.41 Impact Factor
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    ABSTRACT: The past two decades have witnessed an increase in prevalence of food allergy that has been matched with a tremendous progress in research that has led to better understanding of pathogenic mechanisms and development of novel therapies for food allergy. Establishment of murine models of peanut and cow's milk allergy has been extremely useful in investigating food allergy treatments. Diverse strategies for prevention and treatment of established food allergy are being evaluated. Anti-IgE antibody therapy, Chinese herbal medicines, and killed bacteria expressing modified major peanut allergens represent the most promising approaches that will lead to development of therapy for patients for whom no effective treatment is currently available.
    Inflammation & Allergy - Drug Targets (Formerly ?Current Drug Targets - Inflammation & Allergy) 02/2006; 5(1):23-34. DOI:10.2174/187152806775269349
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