Embryonal rhabdomyosarcoma of the chest wall: a case report and review of the literature.

Department of Pathology, M. S. Ramaiah Medical College and Hospital, Bangalore, India.
Indian Journal of Pathology and Microbiology (Impact Factor: 0.64). 05/2008; 51(2):274-6. DOI: 10.4103/0377-4929.41694
Source: PubMed

ABSTRACT Embryonal rhabdomyosarcoma is a soft-tissue sarcoma which has a predilection for the head and neck area, genitourinary tract and the extremities. We report a rare case of embryonal rhabdomyosarcoma of the chest wall in an 8-year-old girl, presenting as a destructive tumor in the rib and clinically and radiologically mimicking Ewing's sarcoma. Histopathological examination showed a small round cell tumor. Immunohistochemically, the positivity for muscle markers desmin and myogenin in the tumor cells proved to be useful for making a definitive diagnosis of embryonal rhabdomyosarcoma. Cytogenetic analysis revealed a high level of aneuploidy in the tumor cells, with double-minutes and additional chromosomal structural aberrations. The patient is responding well to chemotherapy.

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