Article

Catalytic antibodies to amyloid β peptide in defense against Alzheimer disease

Chemical Immunology Research Center, University of Texas Houston Medical School, Houston, TX 77030, USA.
Autoimmunity Reviews (Impact Factor: 7.1). 06/2008; 7(5):391-7. DOI: 10.1016/j.autrev.2008.03.004
Source: PubMed

ABSTRACT Immunoglobulins (Igs) that bind amyloid beta peptide (Abeta) are under clinical trials for immunotherapy of Alzheimer disease (AD). We have identified IgMs and recombinant Ig fragments that hydrolyze Abeta. Hydrolysis of peripheral Abeta by the IgMs may induce increased Abeta release from the brain. The catalytic IgMs are increased in AD patients, presumably reflecting a protective autoimmune response. Reduced Abeta aggregation and neurotoxicity attributable to the catalytic function were evident. These findings provide a foundation for development of catalytic Igs for AD immunotherapy.

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